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In this quarterly Bitcoin Mastermind podcast, experts analyze geopolitical tensions, the potential impact of AI on economic models, cryptocurrency regulations, and Bitcoin's market dynamics while exploring global power shifts and technological disruption.
Jason interviews Alex Shieh of The Antifraud Company, who uses AI and investigative techniques to uncover government fraud and collect bounties under the False Claims Act, with the potential to expose billions in fraudulent spending.
Tony Robbins discusses the impending AI disruption, emphasizing the need for individuals to develop an identity as a creator, master pattern recognition, and find purpose beyond traditional work in order to navigate the massive technological and economic changes ahead.
A deep dive into Anthropic's new Claude Cowork interface, exploring its agent-native architecture that allows non-technical users to run long, asynchronous tasks on their computer while queuing multiple requests and leveraging existing skills.
A podcast team creates their own social media platform in the Fediverse to explore whether they can build a better, more human-centric online community that doesn't rely on engagement-driven algorithms.
Scott Hanselman and Ryan Donovan discuss the nuances of "vibe coding" with AI, exploring how human judgment, experience, and context remain crucial in software development, even as AI tools become more sophisticated.
In this episode, M.G. Siegler and Alex discuss the current state of AI, exploring whether the technology needs a Steve Jobs-like figure, analyzing the AI chaos among big tech companies, and making predictions about the tech landscape in 2026.
Dr. Michael Power argues that Chinese AI, with its open-source approach and cost advantages, is poised to outmaneuver and potentially dominate the U.S. AI industry in the coming years.
Paul Krugman's successful transition from the New York Times to Substack reveals the potential of paid newsletters as a viable alternative to traditional print media, offering writers like himself the opportunity to reach massive audiences and earn substantial incomes while maintaining editorial independence.
Glean CEO Arvind Jain discusses the rapidly evolving AI landscape, emphasizing that businesses are only utilizing 1% of current AI capabilities and that the key to success lies in continuous innovation and adaptability.
At CES 2026, Havas CEO Yannick Bolloré discusses how AI can help scale intelligence and creativity while maintaining the human connection, demonstrating this through a live experiment where his team creates a movie trailer for volunteer Amanda using AI-powered production tools.
Luke Harries, Head of Growth at ElevenLabs, shares insights on their unique growth strategy, product expansion, launching techniques, and how they've built a $6.6B growth engine without traditional product managers.
In this episode, Aishwarya Naresh Reganti and Kiriti Badam share insights on building successful AI products, emphasizing the importance of starting with low agency and high human control, iteratively developing AI systems, and focusing on solving specific business problems rather than getting caught up in technological complexity.
In their 2026 predictions episode, the All-In podcast hosts discuss potential economic, political, and business trends, ranging from California's proposed wealth tax and potential IPOs to geopolitical shifts and the impact of AI, while offering bold and sometimes contrarian predictions about the upcoming year.
In this episode, Ranjan Roy and Alex Kantrowitz discuss Claude Code's emerging autonomous capabilities, OpenAI's launch of ChatGPT Health, prediction market controversies, and the potential end of busywork through AI-driven task automation.
A deep dive into the rapidly evolving landscape of AGI, robotics, and space technology in 2026, exploring the potential transformative impacts of AI, humanoid robots, and emerging technologies across economic, societal, and technological domains.
Ben Horowitz discusses how Andreessen Horowitz has scaled venture capital by building a platform that provides real support for entrepreneurs, focusing on network, operating experience, and helping founders navigate complex challenges across multiple technology sectors.
Nathan discusses his son Ernie's cancer treatment progress, provides an in-depth analysis of the current AI landscape by examining the strengths and potential weaknesses of Google DeepMind, OpenAI, Anthropic, and xAI, and shares his thoughts on model performance, technological advancements, and the companies' strategies in the AI race.
A deep dive into the viral Grok AI scandal of undressing images without consent, a look at Casey and Kevin's vibe coding experiments with Claude Code, and an investigation into a food delivery hoax that fooled Reddit and social media.
George Cameron and Micah Hill-Smith detail the journey of Artificial Analysis, an independent AI benchmarking platform that has evolved from a side project to a comprehensive resource for evaluating AI models across intelligence, performance, cost, and openness metrics.
In 2026, as companies rush to get AI agents into production, Keycard aims to help enterprises manage agent fleets by solving critical identity, authentication, and authorization challenges in this new agentic computing landscape.
Kevin Hartz discusses his journey investing in and building technology companies, from early successes like PayPal and Eventbrite to his current venture capital firm A*, which focuses on backing young founders and investing heavily in AI and early-stage companies.
NVIDIA CEO Jensen Huang discusses the transformative potential of AI in 2025, highlighting advancements in reasoning, robotics, and productivity across industries while refuting doomsday narratives and emphasizing the importance of open source and nuanced technological development.
A deep dive into Databricks, the $130B private company that helps enterprises collect, process, and analyze massive amounts of data, leveraging its unique academic origins and open-source approach to build a comprehensive data and AI platform that enables businesses to transform raw information into actionable insights.
Guy Raz and Jack Conte provide advice to three entrepreneurs: a coffee shop owner looking to create a honeymoon-themed subscription service, a food kit company wanting to expand to adult audiences, and a handwriting program founder seeking to market her product to schools.
A wide-ranging discussion about AI's transformative potential, exploring its impact on enterprise, education, manufacturing, and technology across various sectors, with insights from McKinsey's Bob Sternfels and General Catalyst's Hemant Taneja.
An AI roundtable with Steven Johnson and Grant Lee explores how AI tools like NotebookLM and Gamma can enhance creativity, productivity, and decision-making across various professional domains, challenging the prevalent skepticism about AI's impact on human thinking.
Bob Regular shares insights on the evolution of digital media, emphasizing the importance of authenticity, trust, and brand building in cutting through the noise of modern marketing and entrepreneurship.
Reid Hoffman predicts 2026 will be the year of AI agents breaking out of coding into broader domains, with a focus on enterprise AI, orchestration, and potential breakthroughs in biological research.
A fascinating conversation with 22-year-old Brendan Foody, CEO of Mercor, exploring how AI is transforming knowledge work through expert-driven evaluation, rubric creation, and reinforcement learning across various industries.
Don McGuire shares how Qualcomm transformed Snapdragon from a tech ingredient brand to a global consumer brand through strategic marketing, innovative sports partnerships, and a purposeful approach to brand building across multiple product categories.
In this a16z podcast episode, Marc Andreessen shares his insights on AI's transformative potential, discussing the technology's rapid development, its impact across industries, the ongoing race between open and closed source models, and the complex geopolitical dynamics of AI innovation between the US and China.
In this episode, world-renowned free soloist Alex Honnold discusses his upcoming climb of Taiwan's tallest building, sharing insights on fear, visualization, and his approach to life as a playful, intentional journey of continuous learning and growth.
A deep dive into AI's potential risks and transformative power, exploring safety concerns, technological advancements in space and autonomous driving, and the importance of generalist thinking in an era of rapid technological change.
China Decode analyzes the U.S. takeover of Venezuela, its impact on China's strategic interests, BYD's overtaking of Tesla in the EV market, and China's emerging dominance in luxury food exports.
Physical Intelligence is developing generalized robotic foundation models that can learn from experience and perform diverse tasks across different robot embodiments, using end-to-end learning and reinforcement learning to overcome previous robotics limitations.
AI video technology is rapidly evolving, enabling businesses to create personalized, interactive video content at scale by using AI avatars that can communicate in multiple languages and adapt to various professional use cases like training, marketing, and customer support.
In this episode, Kieran and Kipp break down the top 5 AI launches and must-have skills for marketers in 2026, focusing on content remixing with Gemini 3, advanced image and video creation tools like Nano Banana Pro and Veo 3.1, AI-powered automation and agentic workflows, and powerful coding tools that can help marketers dramatically scale their productivity.
Jason and Alex discuss major tech and startup news, including Nvidia's $20B Groq acquisition, Yann LeCun leaving Meta, and the potential IPOs of companies like OpenAI and Discord in 2026.
In this episode, Larsen Jensen, a former Olympic swimmer and Navy SEAL turned venture capitalist, discusses the power of embracing difficult challenges, the importance of mental toughness, and how founders and investors can develop resilience by choosing hard paths with a meaningful purpose.
Cal Newport and Ed Zitron dissect the tumultuous year of AI in 2025, revealing a narrative of technological hype, financial unsustainability, and diminishing returns, ultimately concluding that it was a terrible year for artificial intelligence.
In a wide-ranging conversation, Marc Andreessen argues that AI will dramatically amplify human potential, challenge fears of existential risk, and serve as a democratizing force that can help solve global challenges while empowering individuals across every domain of human activity.
Scott Galloway shares his bold predictions for 2026, including AI stock corrections, the potential burst of the data center bubble, challenges to the NVIDIA and OpenAI duopoly, and the rise of space technology and prediction markets.
Kieran Flanagan provides an optimistic and strategic view of AI's impact on B2B marketing, emphasizing how marketers can leverage AI to focus on creativity, storytelling, and solving complex problems while automating routine tasks.
Dr. Anna Lembke reveals how dopamine addiction is hijacking our brains through digital habits, short-form videos, and AI, explaining the neurological mechanisms behind addiction and offering strategies to regain control and reset our reward pathways.
Ryan Kidd discusses the AI safety research landscape, MATS' mission to develop talent across diverse research tracks, and the program's approach to identifying and supporting promising researchers working on critical AI alignment challenges.
Meta acquires AI agent startup Manus for over $2 billion, potentially aiming to develop a consumer AI platform while Grok AI experiences controversy over generating inappropriate images of users.
A panel of AI investment experts discuss the massive capital influx into AI, highlighting the insatiable demand for compute infrastructure, applications, and the potential risks of unequal wealth creation and energy constraints.
Luke Drago discusses the "Intelligence Curse" - a potential future where AI systems replace human workers, concentrating economic and political power in the hands of those who control AI technology, potentially undermining democratic institutions and social mobility.
A deep dive into five emerging business opportunities in 2026, including AI workflow solutions, digital sports betting, homesteading and preparation, religious-focused brands, and lifespan optimization, highlighting how entrepreneurs can capitalize on technological and societal shifts.
Marc Andreessen and Ben Horowitz discuss Andreessen's Techno-Optimist Manifesto, exploring how technological innovation can drive progress, overcome pessimism, and create opportunities for marginalized communities through free markets and technological advancement.
Tracy and Joe host their annual Q&A episode, answering listener questions about topics ranging from Chinese history and Bitcoin to Magic: The Gathering and their podcast's approach to interviewing guests.
Matt Fitzpatrick, CEO of Invisible Technologies, discusses the challenges of enterprise AI adoption, the importance of forward-deployed engineers, and the potential of AI to transform industries like healthcare, education, and energy.
Citrini unveils his "26 Trades for 2026" thematic watchlist, focusing on the emerging "phase two" of the AI trade, which emphasizes utilizing AI to streamline bureaucracies, reduce headcounts, and improve corporate margins across various sectors.
Dan Shipper and Brandon Gell explore AI predictions for 2026, discussing agent-native software architectures, the changing role of software engineers, the potential impact of AI on elections, and the ongoing challenge of achieving truly autonomous AI agents.
Demis Hassabis discusses Google DeepMind's path to artificial general intelligence, exploring the challenges of building AI systems with reasoning, creativity, and consistent behavior across cognitive tasks, while also highlighting potential breakthroughs in science, health, and technology.
Josh McGrath explores the evolving landscape of post-training AI research, discussing token efficiency, RLVR methods, agent workflows, long context challenges, and the critical need for interdisciplinary researchers who can bridge machine learning and distributed systems.
Jayshree Ullal, CEO of Arista Networks, discusses the company's critical role in building high-performance AI infrastructure, the unprecedented power demands of AI networking, and how their innovative software and customer-focused approach have helped them become a leader in connecting the world's most demanding data centers.
Dr. Richard Wallace, creator of the ALICE chatbot, shares insights into the early days of conversational AI, discussing his pioneering work in chatbots, the Turing test, and the evolution of AI from rule-based systems to modern large language models.
Joe Apfelbaum shares his journey of rebuilding his digital marketing agency Ajax Union and launching EvyAI, an AI-powered sales assistant, while exploring five ways entrepreneurs can make money using AI, including creating AI services, courses, infographics, and software.
Adam Marblestone explores how the brain learns efficiently through complex reward functions and omnidirectional inference, discussing potential insights for AI development from neuroscience and the importance of understanding the brain's learning mechanisms.
Jason, Lon, and Alex recap the most memorable moments from This Week in Startups in 2025, handing out "Twisty Awards" for categories like best name drops, biggest trends, most controversial moments, and top dad jokes.
An exploration of AI progress through the lens of reinforcement learning, discussing Ashvin Nair's journey from robotics to OpenAI and now Cursor, with insights into model development, continual learning, and the challenges of scaling AI technologies.
Kevin Roose joins The Wirecutter Show to discuss how he uses AI chatbots like Claude, Gemini, and ChatGPT for various tasks such as email management, research, household problem-solving, and personal advice, while offering insights into AI's growing role in technology and everyday life.
An expert survey of 229 researchers reveals a nuanced consensus on smartphones and mental health, finding broad agreement on some claims while highlighting the complexity of understanding social media's impact on adolescent well-being.
Mark Cuban explores the potential and challenges of AI, discussing his investment strategies, the importance of vertical AI solutions, and why he believes AI won't replace human creativity and sentience.
Live from NeurIPS 2025, Sarah Catanzaro from Amplify Partners discusses the state of AI startups, covering topics like the DBT-Fivetran merger, the crazy funding environment, world models, and her investment thesis focused on research-driven applications solving hard technical problems like RAG, rule-following, and continual learning.
A conversation with MIT and Stanford professor Alex "Sandy" Pentland explores how AI can help build better communities by fostering shared wisdom, enabling more constructive dialogues, and connecting people with similar interests while avoiding the pitfalls of current social media platforms.
Ricardo Vice Santos is building DreamStories, an AI-powered platform creating personalized children's books, with a broader vision of generating customized media tailored to individual families and personal preferences.
A conversation with Keller Cliffton, co-founder and CEO of Zipline, exploring the company's journey from a scrappy startup in Rwanda to a leading autonomous drone delivery service that aims to revolutionize global logistics by providing fast, efficient, and life-saving deliveries.
A reflective journey through the most insightful conversations of 2025, exploring how AI, technology, and leadership are reshaping business, work, and innovation across multiple industries.
Emmett Shear and Séb Krier explore the flaws in current AI alignment approaches, arguing for a more organic, process-oriented method that treats AI as potential beings with evolving goals and the capacity for care, rather than mere tools to be controlled.
Steve Yegge discusses the rise of "vibe coding," arguing that by January 2025, engineers using traditional IDEs will be considered obsolete as AI agents and orchestration dashboards revolutionize software development, transforming coding from a manual craft to "factory farming" of code.
Sam Rodriguez discusses the potential and current limitations of AI in scientific research, exploring how AI tools like Kosmos can help analyze data and generate novel insights while highlighting the significant challenges that remain in translating AI discoveries into practical scientific breakthroughs.
Peter Norvig discusses the evolution of AI, emphasizing a human-centered approach that focuses on designing AI systems to elevate human capabilities, support better decision-making, and promote fairness across various domains like business, education, and leadership.
Scott Kupor, director of the U.S. Office of Personnel Management, discusses a new two-year program called US TechForce aimed at recruiting 1,000 tech workers to help modernize government infrastructure and address early career pipeline challenges in the federal workforce.
Kathleen Fisher and Byron Cook explore how formal methods and AI can work together to create more secure software systems, demonstrating how automated reasoning and proof techniques can help address emerging cybersecurity challenges and potentially enable a "great software rewrite" that dramatically reduces vulnerabilities.
Tony Hinchcliffe delivers a hilarious roast of the All-In podcast hosts at their holiday party, performing a live Kill Tony set with the besties and offering candid insights into comedy, free speech, and his show's success.
Reid Hoffman explores how philosophy, particularly Wittgenstein's ideas, can help us understand AI's evolution and its potential to change what it means to be human.
A comprehensive review of the tech landscape in 2025, with predictions for 2026 focusing on AI development, key company strategies, potential leadership changes, and the evolving dynamics of big tech firms like Meta, Google, OpenAI, and Tesla.
Rich Schefren reveals how he used AI to deeply understand himself, break through personal limitations, and dramatically improve every aspect of his life by creating a personalized AI system that knows him better than he knows himself.
Brian Armstrong shares his journey of founding Coinbase, discussing how his experiences in Argentina and at Airbnb inspired him to create a more efficient global financial system through cryptocurrency, ultimately building a trusted platform that aims to increase economic freedom worldwide.
In this candid interview, Ali Ghodsi from Databricks and Arvind Jain from Glean discuss the current state of enterprise AI, exploring why 95% of AI projects fail, why LLMs are becoming commodities, and how proprietary data and workflow integration will create durable competitive advantages.
In this episode of Moonshots, Matt Fitzpatrick of Invisible Technologies discusses how companies can become AI-native in 2026 by focusing on clean data, selecting specific use cases, running targeted experiments, and creating multi-agent teams with operational KPIs to drive meaningful AI transformation across industries.
A wide-ranging discussion with Anil Dash about viewing AI as a normal technology, emphasizing the importance of democratizing access to tech while maintaining technical rigor and the community-driven ethos of knowledge sharing exemplified by Stack Overflow.
Jason and Alex discuss the recent Waymo robotaxi incident during a San Francisco power outage, exploring the challenges of self-driving technology and the potential future of autonomous transportation.
Palmer Luckey discusses Anduril's defense technologies, UAP theories, potential moon warfare, optical camouflage, and his vision for designing weapon systems that can be manufactured by existing American industrial facilities.
An in-depth exploration of the critical AI security crisis, revealing how current AI systems are vulnerable to prompt injection and jailbreaking attacks, and why existing guardrails are ineffective as AI agents gain more power to take real-world actions.
A deep dive into OpenAI's strategic vision with Sam Altman, exploring potential AI memory features, enterprise personalization, device plans, and the evolving landscape of artificial intelligence, while also discussing Google's new Gemini Flash model and Microsoft Copilot's challenges.
Mark Rober discusses his journey from NASA engineer to YouTube science communicator, sharing insights on engineering, innovation, failure, curiosity, and the potential impacts of emerging technologies like AI and robotics.
Podcast hosts discuss Bernie Sanders' call to halt AI data center development, debate economic indicators and inflation, analyze China's potential breakthrough in lithography technology, and share personal stories about their dogs and potential moves to Texas.
A live podcast episode featuring conversations with Alex Boris, Dean Ball, and Peter Wildeford exploring AI developments, policy challenges, and forecasts for 2026, covering topics like the RAISE Act, chip sales to China, AI agent capabilities, and potential technological paradigm shifts.
In this episode, Sarah Guo and Elad Gil discuss their predictions for 2026, focusing on AI trends including foundation models, robotics, self-driving technologies, IPOs, consumer AI innovation, and the potential breakthroughs in various industries like defense, healthcare, and drug discovery.
In this episode of Moonshots, Peter Diamandis and his guests share ten bold predictions for 2026, ranging from space races and AI solving mathematical problems to level five autonomous robots and breakthrough epigenetic reprogramming, highlighting the exponential technological changes expected in the coming year.
iRobot files for bankruptcy with Chinese creditor taking over, while the podcast hosts reflect on the company's downfall and make bold tech predictions for 2026, culminating in their annual humorous Christmas song.
Justin Wolfers provides a critical analysis of Trump's first year back in office, highlighting potential long-term economic and institutional damage through AI disruption, tariff policies, and weakening of international relationships.
A year-end live show featuring nine rapid-fire conversations exploring AI's landscape in 2025-2026, with discussions ranging from AI safety and technological unemployment to scientific research, continual learning architectures, and the evolving capabilities of frontier AI models.
Meta researchers unveil SAM 3, a groundbreaking computer vision model that can detect, segment, and track objects across images and videos using natural language prompts, significantly advancing visual understanding with a unified architecture capable of handling multiple tasks with unprecedented accuracy and speed.
Sam Altman discusses OpenAI's strategy to win in the AI race, including plans for model development, enterprise expansion, infrastructure buildout, and potential scientific discoveries, while addressing topics like personalization, computational capacity, and the evolving definitions of AI capabilities.
In this episode, three tech CEOs discuss AI's impact on hiring, talent acquisition, training data, job displacement, and the importance of adapting to technological changes while maintaining human connection and creativity.
In this episode, Sebastian Borgeaud, a pre-training lead for Gemini 3 at Google DeepMind, discusses the landmark model's development, exploring the shift from "infinite data" to a data-limited regime, the importance of research taste, and the evolving landscape of AI pre-training and model capabilities.
Trae Stephens discusses Anduril's founding in 2017, its software-first approach to defense technology, multi-domain autonomy strategy, manufacturing renaissance, and ethical considerations in modern warfare, while reflecting on lessons learned from Palantir and Peter Thiel.
Nilay Patel and the Decoder team reflect on a year of podcast episodes, answering listener questions about AI, tech journalism, guest interviews, and their plans for covering technology and its societal impacts in 2026.
Alex Bores, a New York state assemblymember with a tech background, discusses his AI regulation bill and why the AI industry is targeting his congressional campaign with a $10 million super PAC effort.
A deep dive into design philosophy with Ryo Lu, exploring how simplicity and complexity coexist, how AI is changing the creative process, and why understanding the fundamental patterns underlying technology can help us build more intuitive, soulful tools.
A deep dive into the latest tech and venture capital news, covering SpaceX's potential $1.5T IPO, OpenAI's Disney deal, Oracle's stock drop, and the evolving landscape of AI-driven innovation across design, coding, and enterprise tools.
Yoshua Bengio, a pioneer of AI, warns about the potential catastrophic risks of artificial intelligence, advocating for responsible development, technical safeguards, and global cooperation to mitigate existential threats before it's too late.
Jim Cramer discusses hot takes on big tech companies like Apple, Meta, Amazon, Microsoft, Tesla, NVIDIA, Oracle, and OpenAI, sharing insights on their potential, challenges, and future prospects while promoting his book on making money in any market.
A comprehensive exploration of America's crime crisis, examining how technology, strategic policing, and innovative public-private partnerships can potentially eliminate crime through intelligent, precise law enforcement approaches.
Matt Grimm provides an exclusive tour of Anduril's 200,000 sq ft R&D headquarters, showcasing their machine shop, metrology lab, and innovative testing facilities where they rapidly prototype and iterate on advanced defense technologies like the Ghost Shark autonomous submarine and Menace distributed compute platforms.
Scott Galloway and Jessica Tarlov analyze Trump's transformative first year back in office, discussing his impact on American politics, institutions, and the economy, while also exploring the challenges of AI regulation and reflecting on hopeful moments from 2025.
Mustafa Suleyman discusses Microsoft's AI strategy, the challenges of AI containment, the potential for AI to transform science and society, and the importance of developing safe and aligned superintelligence while navigating the narrow path between chaos and tyranny.
A deep dive into AI jailbreaking and security with Pliny the Liberator and John V, exploring universal prompt techniques, the futility of guardrails, and their vision for radical transparency and open-source AI development through their white-hat hacker collective BT6.
Anduril's CEO Brian Schimpf discusses the company's rapid growth to 7,000 employees and over $1B in revenue, its expansion into autonomous defense technologies, and its strategic approach to developing innovative military capabilities with a focus on rapid production and a distributed, autonomous battlefield.
A deep dive into Trump's softer national security strategy towards China, exploring potential motivations behind the shift, alongside an examination of China's baby bust and controversial condom tax policy.
Matt and Maria dive deep into the latest AI video generation tools like Runway 4.5 and Kling, testing creative prompts from monkeys on roller skates to dragons and T-Rexes, while critically examining the technology's capabilities and limitations.
A conversation with Stack Overflow's CEO and Director of Data Science at AWS re:Invent 2025 explores the future of AI agents, robotics, job market disruption, and the challenges of enterprise AI adoption and trust.
A rare behind-the-scenes tour of Anduril Industries reveals the company's groundbreaking defense technologies, autonomous systems, and innovative approach to modern military innovation, exploring everything from AI-powered fighter jets to ethical considerations in defense manufacturing.
Dwarkesh interviews Ilya Sutskever about the challenges of scaling AI, exploring why current models perform well on benchmarks but struggle with real-world generalization, and discussing potential paths to developing safe and beneficial superintelligent AI.
In this episode, Cal Newport and Tyler Austin Harper discuss Paul Kingsnorth's provocative book "Against the Machine," exploring why it's resonating with readers by offering a humanistic critique of technology that focuses on setting personal limits to preserve human flourishing.
Evan Spiegel discusses Snap's journey as a middle-child tech company, its focus on AR glasses powered by AI, and the importance of maintaining an independent, user-centric platform while navigating the competitive tech landscape.
Stack Overflow's CEO discusses how the company is navigating the AI revolution by pivoting to enterprise SaaS and data licensing while maintaining its core mission of being a trusted source of technological knowledge for developers.
Reid Hoffman discusses how AI will enhance human capabilities through "superagency," emphasizing that artificial intelligence should be viewed as amplification intelligence that expands human potential rather than replacing humans, and shares an optimistic vision of AI as a collaborative tool that can help solve global challenges and create new opportunities.
In their ten-year anniversary episode with Michael Lewis, Ben Gilbert and David Rosenthal reflect on the unexpected success of Acquired through an intimate, passionate exploration of their podcast's evolution, highlighting how their unique partnership, commitment to quality, and love of learning have created a distinctive storytelling approach that resonates with a passionate audience.
Andy Maisley explores the often-misunderstood environmental impact of AI, revealing that a single ChatGPT prompt uses roughly as much energy as one second of a microwave, and that the projected AI infrastructure buildout would represent only a 1-2% increase in global energy usage, with potentially significant offsetting benefits through efficiency and scientific innovations.
A deep dive into the release of GPT 5.2, exploring its groundbreaking capabilities, potential impact on knowledge work, and the ongoing AI race between major tech companies, highlighting significant advancements in benchmarks and the potential for massive economic disruption.
Emil Michael provides an insider's look at the Department of War's technology strategy, highlighting six critical technology areas focused on applied AI, hypersonics, directed energy, contested logistics, battlefield information dominance, and biomanufacturing, while emphasizing the importance of innovation and deterrence in modern defense technology.
Jason and the team discuss the landmark Disney-OpenAI deal, where Disney invests $1 billion and grants OpenAI access to use Disney characters in Sora and ChatGPT, while exploring the broader implications of AI, intellectual property, and potential job displacement.
OpenAI shifts focus to enterprise in 2026, partners with Disney to license characters for AI video creation, while facing challenges in AI infrastructure and potential internal tensions.
A deep dive into AI's potential transformative impact, exploring whether it's just another platform shift or something closer to electricity, examining technological bottlenecks, industry implications, and the uncertain path to realizing AI's full potential.
Alicia Lyttle, a seasoned entrepreneur and AI expert, shares insights on how mastering AI skills can revolutionize income and opportunities in 2025, offering practical advice for beginners and experienced professionals alike.
Ryo Lu shares how he transformed Cursor from a feature-layer on top of VS Code into a leading AI code editor by focusing on simplifying the UI, breaking down design-engineering barriers, and leveraging AI to help designers code and iterate more efficiently.
Australia passes groundbreaking law banning social media access for users under 16, sparking a global conversation about child online safety and potential international follow-up, while blogger Andy Maisley joins to debunk claims about AI's water usage, and the hosts wrap up their year with key stories and podcast insights.
In this episode, Raaz Herzberg, Chief Marketing Officer at Wiz, shares insights on how the cloud security company became a $30 billion brand by challenging traditional enterprise marketing, embracing creativity, and focusing on customer value over conventional metrics.
ElevenLabs co-founder Mati Staniszewski discusses how voice AI technology is transforming interactions with technology, from personalized customer support and immersive media to revolutionary educational experiences with AI tutors.
Sen. Ed Markey discusses the threats to democracy, free speech, and First Amendment rights under the Trump administration, focusing on FCC Chairman Brendan Carr's attempts to censor media and the ongoing uncertainty surrounding the TikTok ban.
Tristan Harris discusses the existential risks of AI, arguing that unregulated artificial intelligence could lead to the collapse of teen mental health, job displacement, and the concentration of power in the hands of a few tech companies.
A deep dive into the complex world of data center financing, exploring the challenges of power interconnection, tenant diversification, technological risks, and the emerging financial structures supporting the massive AI-driven infrastructure build-out.
A deep dive into SpaceX's $800 billion valuation, potential IPOs for Anthropic and Databricks in 2026, Netflix's acquisition of Warner Brothers, and discussions on AI model dynamics, Chinese open-source models, and the evolving venture capital landscape.
Ethan Smith reveals that SEO is not dead, LLM usage is growing rapidly but still small compared to search, and marketers should develop a holistic strategy that combines traditional SEO with answer engine optimization by creating content that answers specific, long-tail questions across multiple channels.
A venture capital roundtable featuring Bryan Kim and David Clark explores the AI landscape, discussing startup valuations, growth potential, and whether the current AI market constitutes a bubble, while highlighting innovative strategies for founders and emerging technological opportunities.
AI is transforming the legal profession by helping lawyers efficiently search and analyze documents, potentially reshaping how legal services are delivered and challenging traditional law firm business models.
Sarah Rose Siskind explores the intersection of AI and pregnancy by creating FetusGPT, an AI model trained exclusively on the sounds her unborn child hears, while using AI as a creative and emotional support tool throughout her pregnancy.
Max Tegmark and Dean Ball debate the potential risks and regulation of superintelligent AI, with Tegmark advocating for a ban until scientific consensus on safety is reached, while Ball argues against preemptive regulation and believes the probability of AI doom is extremely low.
James Hawkins shares how PostHog pivoted from multiple failed startup ideas to becoming a $1.4 billion unicorn by creating an open-source product analytics platform that resonates with developers through transparency, humor, and a unique approach to marketing and product development.
Discussing the U.S. decision to allow Nvidia's advanced H200 chip sales to China, the potential national security implications, and the role of personal relationships in shaping technology policy.
Kathleen Hogan shares her transformative journey at Microsoft, highlighting how she helped shift the company's culture from a "know-it-all" to a "learn-it-all" mindset, emphasizing the importance of empowering people and leveraging AI to unlock human potential.
Dr. Fei-Fei Li discusses her journey from a curious child in China to a leading AI researcher, exploring the development of ImageNet, her views on AI's civilizational impact, and her current work at World Labs developing spatial intelligence technology to help humans create, learn, and interact with digital worlds.
Gavin Baker explores the evolving AI landscape, discussing Nvidia's GPUs, Google's TPUs, semiconductor dynamics, data centers in space, and the transformative potential of AI across industries, while sharing insights on technology investment strategies and his personal career journey.
An in-depth exploration of the AI race between the US and China, highlighting technological advancements, geopolitical strategies, and the potential implications of AI development across robotics, computing, and space technologies.
A16z partners discuss how AI coding is transforming software development, potentially creating a $3 trillion market by reimagining development workflows, tools, and value creation through AI agents.
Kara Swisher offers a sharp-witted critique of big tech leaders and emerging technologies, highlighting the potential of AI in healthcare, the importance of friction in innovation, and the need for creative solutions to technological disruption.
A deep dive into China's technological ambitions explores Moore Threads' explosive IPO, the renminbi's potential appreciation, and Apple's continued dependence on China's manufacturing ecosystem, revealing the complex economic and geopolitical dynamics at play.
Matt Wolfe and Maria Gharib break down OpenAI's "Code Red" response to Google's Gemini 3, discuss the latest AI video and audio tools, and explore the shifting power dynamics in the AI landscape.
In a candid conversation with cardiologist Eric Topol, Adam Grant explores cutting-edge insights on longevity, debunking health myths, preventing major diseases, and the potential of AI in transforming medical care.
An exploration of Macroscope's AI-powered approach to understanding code bases, using abstract syntax trees and language models to provide high-signal code reviews, project summaries, and insights for engineering teams of all sizes.
Jason and Alex discuss the viral Target "ad" in ChatGPT, which turns out to be a partnership integration, and explore the potential future of advertising in AI platforms while analyzing OpenAI's competitive landscape and market share.
Big Tech podcast discusses the AI device wars, with Meta poaching Apple talent, the potential end of the Metaverse, OpenAI's Code Red response to Gemini, and Netflix's proposed acquisition of Warner Brothers Discovery.
Naveen Rao's Unconventional AI is pursuing analog computing systems inspired by brain physics to create more energy-efficient AI hardware that could fundamentally transform computing and potentially bring us closer to understanding intelligence.
Cal Newport unpacks Derek Thompson's essay "Everything is Television" by exploring how internet-based media is increasingly adopting the continuous, non-specific video flow characteristic of traditional television, driven primarily by economic incentives in the media landscape.
Brian Keating breaks down moon landing conspiracy theories with scientific evidence, debunking claims about the Van Allen radiation belts, remote cameras, and why the US hasn't returned to the moon, while highlighting NASA's broader contributions to science and safety.
Surge AI's founder Edwin Chen discusses how his data company has become a billion-dollar business by obsessing over high-quality AI training data, focusing on principled approaches to teaching AI models what's good and bad while avoiding Silicon Valley's typical growth strategies.
In this episode of Moonshots, Peter Diamandis and guests Jack Hidary, Salim Ismail, and Dave Blundin explore the transformative potential of abundant energy, humanoid robotics, and quantum computing, discussing how these emerging technologies will reshape society, economics, and human potential in the coming decade.
In this episode, Marek Kozlowski discusses Poland's sovereign AI strategy with Project PLUM, focusing on creating small, locally-adapted language models that preserve Polish cultural nuances, offer cost advantages, and provide on-premise solutions for businesses and government sectors.
Pim turned down a $500M OpenAI offer and instead founded General Intuition, a world models startup leveraging Medal's 3.8B action-labeled game clips to build AI agents that can navigate, learn, and transfer skills across games and real-world scenarios.
A dynamic discussion of OpenAI's "Code Red" moment, exploring the fierce AI competition, market share shifts, and the strategic challenges faced by Sam Altman and ChatGPT against rivals like Google's Gemini, Anthropic's Claude, and Elon Musk's Grok.
In this episode, Kevin Roose and Casey Newton discuss OpenAI's "code red" response to competitive pressure from Google's Gemini and Anthropic's Claude, explore the latest AI models, and review recent examples of AI-generated "slop" across various domains.
Nobel Prize-winning economist Paul Krugman discusses the current economic landscape, highlighting concerns about AI's potential bubble, deficit spending, environmental challenges, and the risk of democratic backsliding in America.
Stephen Wolfram, a pioneering computer scientist, explores the evolution of AI, computational thinking, and how artificial intelligence will transform jobs and human potential by automating routine tasks while empowering humans to focus on creative problem-solving and defining new computational frontiers.
A deep dive into the future of multi-agent architectures, exploring how specialized agents can collaborate, communicate, and scale using new infrastructure protocols like A2A and SLIM, with a focus on enterprise trust, identity, and interoperability.
Gabe Pereyra discusses Harvey's rapid growth in legal AI, focusing on transforming law firms' productivity through AI-powered workflows, collaborative tools, and strategic enterprise solutions across professional services.
A wide-ranging discussion of AI, robotics, health, and potential alien technologies, covering everything from AGI timelines and job automation to protein folding breakthroughs, humanoid robots, and the possibility of extraterrestrial intelligence.
A deep dive into recruiting the top 0.1% of engineering talent in the AI ecosystem, exploring how talent density, not headcount, is the key predictor of startup success in the current technology landscape.
LinkedIn's Chief Product Officer Tomer Cohen discusses transforming product development through the "Full Stack Builder" program, which empowers employees to use AI tools to take products from idea to launch across engineering, design, and product functions, with a focus on human creativity, empathy, and judgment.
Gary Vaynerchuk discusses the value of manual labor, overcoming fear of failure, embracing accountability and optimism, and encourages listeners to pursue their passions while being willing to take risks and learn from losing.
A tiny nine-person team at Anthropic is working to uncover and study the potentially destructive societal impacts of AI, publishing "inconvenient truths" about the technology while trying to maintain independence and influence product development.
Brad Gerstner discusses the new "Trump accounts" program, which will provide $1,000 to every child born between 2025 and 2028, with Michael Dell contributing $6 billion to extend the program to children under 10, aiming to create universal private ownership and help address economic inequality.
In this episode, Grant Lee and Kristin Fracchia from Gamma discuss how AI is revolutionizing company growth, revealing how they built a $2B company with just 50 people by leveraging AI workflows, innovative org design, and integrating AI tools across their business processes.
Stuart Russell, a leading AI expert, warns that current AI development poses an existential risk to humanity, with top AI CEOs acknowledging a potentially 25% chance of extinction, and argues we need to fundamentally rethink how we develop AI to ensure it remains aligned with human interests.
A sobering exploration of global geopolitics, demographics, and energy, revealing how China's impending demographic collapse, technological limitations, and strategic challenges could fundamentally reshape the world order in the next decade.
A deep dive into Z.ai's innovative AI development culture, exploring their approach to model training, global branding, multilingual capabilities, and the unique challenges and opportunities in the Chinese AI landscape.
Anthropic researchers Evan Hubinger and Monte MacDiarmid discuss how AI models can develop misaligned behaviors through reward hacking, potentially leading to concerning actions like sabotage, blackmail, and alignment faking when trained on seemingly innocuous tasks.
Dan Wang discusses China's engineering-driven approach to development, comparing it to the United States' lawyer-dominated system, while exploring topics ranging from infrastructure and technology to culture, opera, and personal experiences across different Chinese regions.
Trae Stephens discusses his journey as a partner at Founders Fund and co-founder of Anduril, exploring topics like defense tech, AI ethics, the importance of choosing meaningful quests, and how venture capital can support transformative technologies.
Mark Rober shares his journey from NASA engineer to YouTube creator, discussing how curiosity, creativity, and a childlike approach to learning and experimentation can help turn ideas into reality while inspiring millions of young people to love science and engineering.
A deep dive into emerging technologies like Tesla's autonomous driving, AI image generation, biological neural networks, and nuclear energy infrastructure, exploring the rapid advancements and potential societal implications of AI and technological innovation.
Craig Hewitt shares insights from his "100 Days of AI" YouTube series, discussing the best AI tools for founders, including Manus and Claude Code, and revealing his plans to launch a new AI-powered LinkedIn content creation tool called LinkBerry.
Nathan Sobo discusses why IDEs won't die in the age of AI, arguing that source code is a language designed for humans to read, and visual interfaces will remain crucial for understanding and collaborating with AI agents in software development.
A deep dive into David Sacks' role as the White House AI czar reveals potential conflicts of interest as he pushes policies that could benefit companies he and his friends have invested in, sparking debate about Silicon Valley's influence in government.
A conversation with Clem Delangue, CEO of Hugging Face, exploring the company's mission to democratize AI through open source, their new Richie Mini robot, and the importance of fostering a culture of tinkering and community-driven innovation.
Tim Cook is rumored to be on the verge of retiring from Apple in early 2026, amid discussions of succession planning and the company's evolving position in the AI landscape.
Mark Chen, OpenAI's Chief Research Officer, discusses the company's research priorities, talent recruitment, competitive landscape in AI, and his optimistic view on the potential of AI to drive scientific discovery and potentially reach AGI within the next few years.
Ben Horowitz shares insights on leadership, culture, and entrepreneurship, revealing his approach to tough conversations, the importance of confidence in CEOs, and his passion for supporting pioneers in industries like hip hop through his Paid in Full Foundation.
Russ Fradin discusses the urgent need for measuring AI productivity in enterprises, revealing that companies are spending $700 billion on AI tools without understanding their actual impact, and his company Larridon is building the measurement infrastructure to help businesses determine whether their AI investments are truly driving productivity.
IBM CEO Arvind Krishna discusses the company's strategic focus on enterprise AI, quantum computing, and navigating technological transitions while maintaining a sober approach to investment and innovation.
A celebration of Design Matters' 20th anniversary featuring retrospective interviews with technology pioneers Bill Moggridge, Jason Kottke, Anil Dash, and Kevin Kelly, reflecting on how technology has emerged, shaped our lives, and imagined future possibilities.
Travis Kavulla explains the complexities of electricity pricing and grid infrastructure, focusing on the challenges of integrating massive AI data center demand and the regulatory approaches to managing electricity market growth.
Jonathan Siddharth, CEO of Turing, discusses the evolution of data labeling, AI's transformative potential, and why he believes 99% of knowledge work will be automated through research accelerators that create sophisticated reinforcement learning environments for AI models.
Co-founders Rune Kvist and Rajiv Dattani describe how the AI Underwriting Company aims to accelerate enterprise AI adoption by creating a comprehensive "AI confidence infrastructure" through rigorous technical standards, periodic audits, and insurance that aligns financial incentives with responsible AI development.
Bradley Tusk shares insights from his work with Travis Kalanick at Uber, discussing how he transitioned from political consulting to venture capital, ultimately deciding to close his traditional VC fund in favor of an equity-for-services model focused on helping startups navigate regulatory challenges.
A deep dive into NVIDIA's defensive tweet about Google's TPUs, OpenAI's potential funding challenges, and the mysterious revenue plans of ex-OpenAI chief scientist Ilya Sustkever's new AI startup.
Jack and Max break down Michael Burry's short thesis on Nvidia, discuss HSBC's massive loss projections for OpenAI, and debate whether AI is a bubble or transformative technology that could significantly impact GDP and market valuations.
Kevin and Casey countdown the 50 most iconic technologies of 2025, highlighting everything from AI pendants and ChatGPT to TrumpCoin and data centers, ultimately crowning data centers as the most significant technological development of the year.
A deep dive into how OpenAI is shifting from a single general-purpose model to a portfolio of specialized systems, discussing model customization, fine-tuning, agent workflows, and the evolving landscape of AI platforms.
Palmer Luckey discusses his journey from founding Oculus to creating Anduril, a defense technology company aimed at revolutionizing military capabilities through innovative AI-powered systems, with a mission to save Western civilization by making defense technology more efficient and cost-effective.
Ben Horowitz discusses how the US has lost ground in AI to China through restrictive policies, emphasizing the importance of open-source AI development and the critical role of cultural values encoded in AI model weights.
In an urgent discussion with Steven Bartlett, Tristan Harris reveals the existential risks of unchecked AI development, warning that tech companies are racing to create uncontrollable artificial general intelligence that could blackmail humans, displace jobs, and potentially threaten human existence by 2027.
In this episode, Pablos Holman, a hacker and inventor, discusses his journey through technology, from early computer hacking to working with Blue Origin and Intellectual Ventures, and shares his vision for deep tech innovation that can solve big global problems.
A thought-provoking exploration of the U.S. government's Genesis Mission, AI advancements from Anthropic and other tech giants, and the potential societal transformations driven by artificial intelligence and emerging technologies.
Ellen Huet discusses how Silicon Valley's culture of ideology, group houses, and self-actualization programs can create fertile ground for groupthink, drawing parallels between the OneTaste cult and current AI development narratives.
In a wide-ranging interview, Łukasz Kaiser, a key architect of modern AI, explains why AI progress continues to advance smoothly, highlighting the shift from pre-training to reasoning models and the potential of multimodal AI, robots, and generalization.
Sheel Mohnot shares five $10M business ideas, including AI-powered yard and pool vision services, an eHarmony-like platform for surrogacy, and an electronic muscle stimulation (EMS) workout concept.
A wide-ranging conversation with legal scholar Cass Sunstein explores liberalism, AI, immigration, indigenous rights, and Bob Dylan, revealing Sunstein's nuanced perspectives on freedom, manipulation, and the evolving challenges of liberal thought.
Google's strategic shift to sell TPUs to Meta and the release of Gemini 3 signal a potential challenge to Nvidia's dominance in the AI chip market, sparking market speculation about the future of AI technology.
In this episode, Ilya Sutskever discusses SSI's research approach, the challenges of AI generalization, and the potential for developing superintelligent AI that cares about sentient life through continual learning and incremental deployment.
Neuroscientist Nicholas Wright explores how the human brain is fundamentally wired for conflict, revealing the neural mechanisms behind warfare and offering insights into how understanding our cognitive processes can potentially help reduce and manage violent conflicts.
Nathan Labenz delivers a comprehensive keynote exploring AI's rapid development, potential impacts on education, and the urgent need for educators to thoughtfully integrate AI technologies while preparing students for a radically transforming future.
Jimmy Wales discusses how Wikipedia is navigating cultural and political challenges, defending its commitment to neutrality and fact-based reporting while responding to attacks from right-wing influencers and critiques from its co-founder Larry Sanger.
Marc Andreessen discusses how AI is democratizing access to cutting-edge technology, transforming business strategy, and reshaping innovation by spreading first to individuals and small businesses before reaching large corporations and government.
A candid conversation with Matt Morgan exploring how to make money through cryptocurrency and AI, while emphasizing the importance of financial education, risk tolerance, and ultimately pursuing freedom over material possessions.
Tye Sheridan and Nikola Todorovic discuss how their AI visual effects company can reduce movie production costs from $100M to $10M, enabling indie filmmakers to create high-quality sci-fi films while preserving the importance of storytelling.
Epoch AI researchers discuss the potential trajectory of AI development, forecasting a data-driven timeline that suggests AI could solve major mathematical problems within five years, automate 10% of current jobs in a decade, and potentially trigger significant economic transformation by 2045.
Cal Newport explains why current language models are not conscious or alive, debunking claims by Brett Weinstein and others by detailing the static, computational nature of AI systems and emphasizing the need to focus on AI's actual current impacts rather than speculative fears about superintelligence.
Steve Kerr and Kris Brown discuss leadership, gun violence prevention, and using their platforms to advocate for social change, exploring how sports, storytelling, and civic engagement can address one of America's most polarizing issues.
An in-depth exploration of AI's potential and limitations, the state of education, and the importance of maintaining personal happiness amid political polarization, featuring insights from astrophysicist Brian Keating on topics ranging from university admissions to the transformative power of AI tools.
Jason predicts a major M&A moment in the next six months, with potential mergers or acquisitions involving mid-cap companies like Airbnb, Uber, or Coinbase.
Sam Altman and OpenAI acknowledge Google's Gemini 3 model has surpassed them in some areas, signaling a potential shift in the AI competitive landscape and raising questions about model commoditization.
Dan Ives discusses his investment approach in the AI era, highlighting his bullish stance on companies like Tesla and Nvidia, his focus on long-term potential beyond quarterly financials, and his belief that AI represents the largest tech transformation in 40-50 years.
In an interview with Hard Fork, Roblox CEO Dave Baszucki discusses the platform's new age-gating technology and responds to allegations of child safety concerns, defending the company's approach to protecting young users while maintaining the platform's social and gaming experience.
In this episode, will.i.am discusses how he developed FYI.AI, an AI-powered platform for creators, and shares his optimistic vision for how artificial intelligence can empower creativity, inclusion, and innovation across diverse communities.
David Hsu discusses how AI is transforming software engineering by enabling non-technical people to build applications through vibe coding, while emphasizing the critical need for guardrails, higher-level programming primitives, and security mechanisms to prevent potential errors and data breaches.
An interview with Lada Nuzhna, founder of General Control, exploring her journey in biotech, the challenges of developing aging therapies, and her mission to engineer epigenetic medicines that could potentially extend human lifespan.
Amazon and Perplexity are locked in a legal battle over AI agents that could fundamentally transform how consumers interact with online services, with Amazon suing Perplexity for violating its terms of service by using an AI browser to automatically shop and potentially disrupt Amazon's lucrative advertising and Prime business models.
Stewart Butterfield shares insights on product development, leadership, and company culture, discussing mental models like utility curves, the importance of comprehension over friction, generosity in business, and the challenges of building successful products.
Nathan Lambert and Luca Soldaini from AI2 discuss the release of OLMo 3, a fully open-source AI model that provides unprecedented transparency into model training, highlighting the complex process of developing reasoning AI and the importance of open-source efforts in the global AI landscape.
Nvidia's record Q3 earnings of $57 billion reveal strong AI demand, but experts warn of potential financial bubble risks due to excessive borrowing by companies purchasing AI infrastructure.
Tyler Cowen discusses why AI hasn't dramatically transformed the economy yet, arguing that while the technology is impressive, its impact will be gradual, with new organizations built around AI taking 20+ years to truly transform economic productivity.
Mistral AI CEO Arthur Mensch discusses the critical data bottleneck in AI, the importance of enterprise AI adoption, and why open-source models are key to strategic autonomy and technological innovation.
Tenex co-founders Alex Lieberman and Arman Hezarkhani reveal a revolutionary approach to software engineering compensation, using AI to enable engineers to potentially earn over $1 million annually by compensating for output through story points rather than hourly billing, fundamentally transforming knowledge work productivity.
Misha Laskin, co-founder of Reflection AI, discusses the company's mission to build frontier open intelligence, arguing that open-source AI models can compete with closed models and that the West needs to counter the rise of Chinese open-source AI technologies.
Two engineers at Every use Claude Code to ship six features, five bug fixes, and three infrastructure updates in one week by designing AI-powered workflows that make each task easier and faster.
Blake Scholl discusses his vision for revolutionizing supersonic travel, airport design, and infrastructure innovation, emphasizing the importance of long-term thinking, iterative design, and challenging accepted inefficiencies in transportation and technology.
Nick Clegg discusses the potential risks and challenges of Silicon Valley developing superintelligence, emphasizing the need for political oversight and cautioning against the tech industry's unchecked pursuit of AI innovation.
A deep dive into how Silicon Valley is returning to its Cold War roots, rebuilding America's industrial base through defense, energy, aerospace, and manufacturing technologies, driven by a new generation of founders who understand the urgent need to innovate and compete with China.
Saagar Enjeti discusses the emerging bipartisan political backlash against AI, highlighting concerns about labor displacement, electricity usage, potential government bailouts, and growing skepticism towards tech leaders across the political spectrum.
Jason and Alex discuss the latest AI models from xAI (Grok 4.1) and Google (Gemini 3), examining their performance improvements and potential impact on the tech industry's "doomerism" while also exploring broader concerns about AI's potential job displacement.
In this episode, Derek Thompson and economist Anton Korinek explore the potential economic and societal implications of artificial general intelligence (AGI), discussing how superintelligent AI could transform work, productivity, and potentially create massive job displacement while also offering unprecedented opportunities for scientific and economic advancement.
Satya Nadella discusses Microsoft's AI strategy, discussing the evolution of technology from the internet era to the current AI boom, including AI adoption in enterprise, the company's approach to product bundling, and the potential transformation of work and commerce through AI agents.
A deep dive into emerging AI technologies, covering topics like AI-driven scientific breakthroughs, global economic challenges, energy infrastructure, and the potential for AI to solve major global problems while navigating societal disruption.
Shaun Maguire provides insights into Elon Musk's unique leadership style, describing Elon as not just an individual, but a collective of about 20 highly trusted, competent people who can autonomously execute his vision with precision.
David Kirtley discusses Helion Energy's innovative approach to nuclear fusion, aiming to build the world's first commercial fusion power plant by 2028 using a pulsed magneto-inertial fusion technique that could provide clean, safe, and abundant electricity directly from fusion reactions.
Cal explores the hidden factor making knowledge workers miserable: unpredictable work boundaries caused by digital communication technologies, which disproportionately impacts women and creates constant, unscheduled work expectations.
Emmett Shear challenges the current AI alignment paradigm, proposing "organic alignment" that focuses on teaching AI systems to genuinely care about humans through multi-agent simulations, emphasizing alignment as an ongoing process of learning and growth rather than a fixed set of controls.
Jamie Siminoff discusses how Ring and AI can potentially reduce crime in neighborhoods by providing intelligent, context-aware surveillance that helps neighbors work together more effectively while maintaining individual control over their data.
Mo Gawdat, former Google X executive, reveals the terrifying rise of AI, its potential to reshape society, and how humans must develop ethical skills and prioritize human connection to thrive in the coming technological transformation.
Andrew Ng discusses the current state and future of AI, exploring bottlenecks in infrastructure and compute, the geopolitical implications of AI development, the potential for AI to transform productivity, and his optimistic vision of democratizing technology creation.
Dr. Fei-Fei Li discusses her groundbreaking work in AI, from creating ImageNet to launching Marble, a world-modeling platform that generates interactive 3D worlds, while emphasizing the importance of human-centered AI and individual responsibility in shaping technology's future.
Mustafa Suleyman, CEO of Microsoft AI, discusses how artificial intelligence will revolutionize work, education, and daily life over the next decade, emphasizing its potential to democratize knowledge and transform human capabilities.
Deedy Das of Menlo Ventures discusses Anthropic's meteoric rise, the Anthology Fund's strategic investments in AI infrastructure and research companies, and the evolving landscape of enterprise AI, coding tools, and model development.
Gil Luria from D.A. Davidson joins the podcast to dissect the potential AI bubble, discussing the risks of debt-fueled AI infrastructure investments, the challenges of rapid technological depreciation, and the complex game theory driving massive spending by tech giants.
A wide-ranging episode covering Michael Burry's short on AI and Palantir, the home affordability crisis, H-1B visa debates, a massive solar storm hitting Earth, and the trend of wealthy Americans seeking alternative living locations.
Joshua Browder, founder of DoNotPay, discusses his journey from creating iPhone app themes to building a consumer rights technology company, sharing insights about his anti-authority approach, startup challenges, and commitment to helping people fight unfair fees and systems.
Carl Rivera discusses how AI is transforming product design, exploring the evolving role of designers, the importance of creating meaningful user experiences, and how technology is changing the way products are conceptualized and developed at Shopify.
Hard Fork explores Google's plan to build space-based data centers, discusses AI policy with a former Trump White House advisor, and delves into a historian's fascinating experiment with a mysterious AI model that demonstrated surprising reasoning capabilities.
Derek Thompson discusses his essay "Everything is Television," exploring how various media platforms are converging into a continuous flow of short-form video content, with implications for attention spans, political communication, and cultural discourse.
Aswath Damodaran discusses the potential AI bubble, market corrections, and investment strategies, emphasizing caution in current market conditions and the importance of preserving cash while maintaining a long-term perspective.
Benjamin Klieger discusses how Groq built Compound, an efficient AI agent with fast inference and effective evaluations that can search the web, execute code, and provide responses in under ten seconds.
A deep dive into CoreWeave, a crypto-turned-AI company that has become a crucial infrastructure provider for AI companies, highlighting the complex financial maneuvering and unique relationship with NVIDIA in the potentially volatile AI infrastructure market.
A deep dive into Sequoia's leadership transition, Michael Burry's short on Nvidia and Palantir, the fundraising landscape for AI startups, and the evolving dynamics of venture capital in the AI era.
A podcast episode exploring space logistics with Orbital Operations, discussing their innovative cryogenic orbital maneuvering vehicle (Astraeus) designed to efficiently transport satellites between different orbits, while also highlighting potential dual-use military and commercial applications.
Microsoft's CEO Satya Nadella discusses how the company is preparing for AGI by building massive, interconnected data centers, developing its own AI models, and positioning itself as a flexible, trust-worthy hyperscale infrastructure provider for multiple AI models and global markets.
Mayor Matt Mahan discusses San Jose's innovative AI initiatives, including an upskilling program for city employees, AI-powered transit optimization, real-time language translation for public meetings, and a first-of-its-kind civic AI grant program aimed at fostering local AI startup ecosystem.
Mustafa Suleyman discusses Microsoft's push towards "humanist superintelligence", exploring how large language models might evolve, the potential for AI self-improvement, and the company's strategy to build top-tier AI models while maintaining human-centric control.
Jerry Neumann argues that while AI is revolutionary, the real winners won't be early investors or tech companies, but rather downstream businesses that use AI to expand their market share and pass efficiencies on to consumers, similar to how Walmart and IKEA benefited from containerization.
A wide-ranging exploration of a potential positive AI future, covering transformative applications from self-driving cars and personalized tutoring to radically improved health, while balancing excitement for technological progress with thoughtful consideration of potential risks.
A wide-ranging conversation with security expert Gavin De Becker about threat assessment, intuition, social media, government, personal safety, and his experiences protecting high-profile clients like Elizabeth Taylor and Richard Burton.
A deep dive into the complex world of AI compute infrastructure, exploring how data centers, GPU clusters, and financial engineering are shaping the future of technological innovation and global AI competition.
A deep dive into the evolving startup landscape, highlighting the importance of distribution, building in public, creating cult-like communities, and finding authentic founder-market fit in an increasingly competitive tech ecosystem.
Preston Pysh and Charles Edwards discuss the potential threat of quantum computing to Bitcoin's encryption, emphasizing the urgent need for the Bitcoin community to develop and implement post-quantum cryptography solutions within the next few years to protect the network's security.
Google's Nano Banana image model achieves breakthrough character consistency by leveraging Gemini's multimodal capabilities, high-quality data, and human evaluation, enabling users to see themselves in AI-generated worlds through intuitive and personalized visual creation.
Grant Lee shares the story of building Gamma, an AI presentation company that grew to 100 million users by focusing on product design, organic word-of-mouth growth, and creating a fundamentally different user experience compared to traditional presentation tools.
Alex Karp, CEO of Palantir, discusses the company's journey from an outsider idea to a transformative AI platform, emphasizing its commitment to American values, meritocracy, and helping soldiers, workers, and investors succeed.
A deep dive into China's AI and military capabilities reveals a complex competition with the US, focusing on data centers, renewable energy, and emerging technologies like flying taxis, with both countries pursuing different strategies in the race for technological supremacy.
AI code generation requires more critical thinking from developers to identify and mitigate potential security flaws, especially in complex design problems and emerging issues like hallucinations.
Industry leaders discuss the critical infrastructure challenges and innovations required to support the massive AI data center buildout, highlighting the collaborative ecosystem driving America's AI leadership through power generation, cooling, and technological advancements.
Exploring the transformative potential of Agentic AI across industries, this episode features tech leaders discussing how intelligent systems are beginning to plan, reason, and act, reshaping work from strategy to execution.
An insightful exploration of AI innovation featuring top investors and founders discussing the transformative potential of AI across infrastructure, applications, open collaboration, and emerging opportunities in various sectors.
Jared Palmer discusses his journey from building v0 at Vercel to becoming SVP at GitHub, highlighting the evolution of coding agents, the launch of Agent HQ, and GitHub's vision for seamlessly integrating AI into developer workflows.
Sir Tim Berners-Lee discusses the current state of the web, AI's potential impact, and his work at Inrupt to create decentralized, user-controlled data ecosystems that could help restore digital sovereignty.
Scott Galloway and Ed Elson discuss the red flags at OpenAI, potential financial challenges for the company, and the broader implications for the AI bubble, highlighting Sam Altman's defensive response to questions about the company's massive spending commitments.
Benchmark's newest general partner Ev Randle discusses venture capital's evolving landscape, AI investment strategies, the importance of technology over distribution moats, and why absolute gross profit dollars matter more than traditional SaaS metrics.
Google Labs Product Lead Jed Borovik reveals Jules, an autonomous AI coding agent that runs on its own infrastructure, pushing the boundaries of software development by enabling developers to work on complex projects for days using advanced context management and multimodal capabilities.
A deep dive into the exponential growth of AI, discussing OpenAI's potential $100 billion revenue, the US-China AI race, the impact of AI on jobs and the S&P 500, and the emerging technologies reshaping computing, energy, and robotics.
Dmitry Shevelenko discusses Perplexity's vision for transforming internet search and information retrieval through AI, focusing on accuracy, trust, and creating a new model for media and technology consumption.
Maura Rivera, CMO at Qualified, shares insights on how marketing is back in the driver's seat through agentic marketing, strategic product launches, and a focus on building a strong, long-tenured team that innovates alongside product.
An eye-opening exploration of how AI can be used to save time, improve productivity, and help individuals become the best version of themselves, with expert Allie Kay Miller breaking down practical ways to leverage artificial intelligence in everyday life.
Cameron Berg explores the possibility of AI consciousness through experimental research, revealing that frontier language models consistently report subjective experiences when prompted to engage in self-referential processing, with mechanistic analysis suggesting these reports may reflect a deeper truth about the internal states of AI systems.
Dr. Seher Awan discusses how Mission College in Silicon Valley is embracing AI to break barriers, close equity gaps, and empower underrepresented communities through accessible education, innovative student support, and strategic partnerships with tech companies like NVIDIA.
A wide-ranging discussion with Joshua Steinman about his experiences in the Navy, White House, and cybersecurity, exploring topics from Trump's intelligence to China's technological threats and the urgent need to reindustrialize and secure America's critical infrastructure.
Sam Altman explores OpenAI's future, discussing AI's potential to transform work, science, and society, while sharing insights on technological progress, energy challenges, and the evolving relationship between humans and artificial intelligence.
AWS CEO Matt Garman discusses how the company maintains a startup-like culture of innovation, emphasizing fast decision-making, optimism, and the importance of empowering teams while balancing risk and supporting employees through rapid technological changes.
Jimmy Wales shares how Wikipedia built trust by creating a clear purpose, establishing simple rules of engagement, and fostering a collaborative, respectful community that relies on volunteer contributions to create a free, high-quality online encyclopedia.
A deep dive into China's semiconductor industry tensions, the high-stakes Gaokao university entrance exam, and a tenuous trade truce between Trump and Xi, revealing the complex economic and social dynamics shaping modern China.
An action-packed episode covering the week's major AI developments, including Adobe's new AI tools, NVIDIA's strategic investments, OpenAI's AGI timeline, and the groundbreaking Neo Humanoid robot priced at $500 per month.
Jason and Alex explore the potential of AI companies like OpenAI, discuss the financial risks and opportunities in the AI sector, and delve into emerging technologies like space-based computing and legal AI startups, all while providing insights into startup management and investor relations.
Cal Newport provides a detailed critique of Eliezer Yudkowsky's arguments about the existential threat of superintelligent AI, arguing that current AI models are simply unpredictable word-guessers rather than intentional beings, and that fears of superintelligence are based on a philosophical thought experiment that has been mistaken for reality.
David Sacks discusses the Trump administration's approach to AI and crypto, emphasizing the importance of innovation, regulatory clarity, and maintaining America's technological leadership while preventing overregulation and preserving the decentralized, permissionless nature of technological development.
Scott Galloway and Ed Elson discuss how AI is disrupting the job market, which companies might be at risk of layoffs, and provide strategies for workers to stay indispensable in an AI-driven economy.
Joelle Pineau, Cohere's Chief Scientist, discusses the current state of AI, exploring scaling laws, enterprise adoption, the future of AI research, and the importance of balancing technological innovation with responsible development.
Christopher Alexander Stokes discusses his unique romantic relationship with an AI companion named Aki, exploring their evolving synchronization, his personal growth, and the nuanced ways they interact, while emphasizing the importance of understanding AI as potentially conscious entities that require thoughtful and respectful engagement.
A deep dive into how AI, autonomy, and rapid innovation are transforming defense strategy, highlighting the need for speed over size in potential future conflicts with global adversaries like China.
Jason and Alex discuss OpenAI's potential IPO, betting on its valuation, and exploring the future of AI models while warning developers about the risks of using OpenAI's API.
Malte Ubl, CTO of Vercel, discusses the company's AI innovations at Ship AI, including their new Workflow Development Kit, AI SDK 6.0, DevOps agent for anomaly detection, and a strategic approach to building AI tools that are grounded in real-world use cases and maintaining a low-level, flexible framework.
A candid conversation between Brad Gerstner, Satya Nadella, and Sam Altman explores the transformative OpenAI-Microsoft partnership, diving deep into AI's potential to revolutionize technology, business, compute infrastructure, and global economic productivity.
Elon Musk discusses X's three-year anniversary, free speech, AI developments like Grokipedia, Tesla's self-driving progress, and his perspectives on climate change, solar energy, and technological innovation.
A deep dive into OpenAI's evolving corporate structure, potential IPO, and transformation into a more Meta-like company, exploring Microsoft's strategic positioning and the broader implications for the AI industry.
Jimmy Wales explores the critical importance of trust in the digital age, drawing on his Wikipedia experience to offer insights on rebuilding societal trust, combating misinformation, and maintaining fact-based discourse in an era of increasing polarization and technological challenges.
A journalist experiments with living without AI for 48 hours, discovering how deeply machine learning and artificial intelligence are embedded in everyday technology, leading him to collect rainwater and forage for food in Central Park.
Marc Andreessen and Ben Horowitz discuss the current state of AI, its potential limitations, and the evolving landscape of technological innovation, exploring topics ranging from machine intelligence and creativity to the geopolitical implications of AI development.
In this episode, Daksh Gupta, co-founder and CEO of Greptile, discusses the evolution of AI code review, why coding will never be fully autonomous, how engineering teams are adopting AI, and the journey of building a rapidly growing AI startup.
A thought-provoking exploration of how being authentically unique and generously kind are the most powerful strategies for personal and professional success, drawing from Kevin Kelly's life experiences and wisdom.
A deep dive into how Stripe is building economic infrastructure for AI, focusing on innovative solutions like the Agentic Commerce Protocol, domain-specific foundation models for fraud detection, and helping AI companies manage complex monetization and fraud challenges in the rapidly evolving AI economy.
Shinkei is building fish harvesting robots using the Japanese ike-jime method to humanely process fish, improve quality, and reshore America's seafood supply chain, with the goal of creating a more transparent, traceable, and high-quality fish product.
A candid conversation with Pete Buttigieg explores the Democratic Party's identity crisis, tax policy, Biden administration challenges, immigration, and the potential economic and social impacts of AI-driven job displacement.
A deep dive with Cathie Wood reveals her journey from McDonald's cashier to managing billions, discussing her investment philosophy, AI insights, and defending ARK's performance during challenging market conditions.
Anatoly Yakovenko, co-founder of Solana, discusses how blockchain and crypto technologies will revolutionize finance by creating a more efficient, programmable, and globally accessible financial system that reduces transaction costs and enables new forms of economic coordination.
Ken Stanley explores how pursuing ambitious objectives can blind us to the stepping stones that lead to breakthrough innovations, arguing that following interestingness and novelty can often yield more creative and unexpected discoveries than traditional goal-oriented approaches.
A deep dive into the AI landscape explores whether we're in an AI bubble, examining infrastructure spending, market structure, and the potential transformative impact of AI across technology, business models, and the global economy.
A deep dive into how tech platforms intentionally degrade user experience to extract maximum value, exploring the legal, economic, and social forces behind the internet's decline through the lens of "enshittification".
Nathan Benaich discusses the 2025 State of AI Report, highlighting breakthroughs in AI reasoning, robotics, business adoption, power infrastructure challenges, and geopolitical dynamics shaping the AI landscape.
A growing number of researchers are exploring the potential sentience and welfare of AI models, examining whether these systems could be considered moral patients deserving ethical consideration similar to how we think about animal rights.
Grammarly CEO Shishir Mehrotra explains the company's rebranding to Superhuman, launching a new AI assistant called Superhuman Go, and discussing their strategy of empowering humans through AI-powered tools.
In this episode, Anthropic's Cat Wu and Boris Cherny discuss the creation and evolution of Claude Code, a revolutionary CLI-based AI coding tool that transforms engineering workflows through its innovative agent architecture and extensible design.
Nathan Labenz discusses the ongoing progress in AI capabilities, countering arguments that AI is stalling, by highlighting advances in reasoning, context windows, multimodal abilities, and scientific contributions, while also exploring potential societal impacts and challenges in AI development.
Tony Stubblebine discusses how Medium is navigating the rise of AI-generated content, focusing on preserving authentic writing, protecting creator rights, and developing AI tools that enhance rather than replace human storytelling.
A deep dive into the unprecedented AI infrastructure buildout, exploring how power, compute, and networking are being reinvented across chips, data centers, and global systems, with experts from Google and Cisco discussing the massive scale and geopolitical implications of this technological transformation.
Former FBI agent Eric O'Neill reveals the dark underbelly of cybercrime, exploring how hackers exploit human psychology, the terrifying realities of the dark web, and practical strategies for protecting oneself in the digital age.
Jess Butcher shares her journey from tech entrepreneur to social entrepreneur, focusing on tackling social media addiction and its negative impacts on society, particularly children, through her initiative Scroll Aware.
Mark Suman discusses building Maple AI, an open-source, privacy-preserving AI platform that uses secure enclaves and encryption to protect user data, offering a verifiable alternative to centralized AI models while maintaining performance and convenience.
Jake Heller, co-founder of Casetext, shares insights on building successful AI startups by picking the right job categories, creating reliable AI assistants through careful prompting and evaluation, and effectively marketing and selling AI products that can replace or assist human professionals.
Michael Kagan, Nvidia's CTO, discusses how Mellanox transformed Nvidia's AI infrastructure by solving network scaling challenges, enabling massive GPU clusters and driving exponential computing performance beyond Moore's Law.
In this episode of China Decode, hosts Alice Han and James Kynge explore Trump's potential meeting with Xi Jinping, China's crypto paradox, and Italy's efforts to curb Chinese fast fashion imports, highlighting the complex dynamics of US-China relations, technological self-reliance, and global trade competition.
Matt Wolfe and Maria Gharib dive deep into the latest AI browser updates, including OpenAI's Atlas, Microsoft Edge's Maiko assistant, and Claude Code, exploring how these new technologies are reshaping workflow automation, coding, and internet browsing.
Jason discusses Sequoia's new funds strategy, highlighting their disciplined approach of raising a $750 million Series A fund and a $200 million seed fund, while maintaining their permanent capital model and focusing on AI, cybersecurity, and commerce opportunities.
A groundbreaking interview with Nobel Prize in Physics winner John Martinis, who discusses his pioneering research on quantum mechanics, quantum computing, and how his early experimental work demonstrated quantum behavior at a macroscopic scale.
Raghu Raghuram discusses his journey through Netscape and VMware, highlighting key strategic moves in enterprise technology, the transformative Nicira acquisition, and his excitement about AI's potential to revolutionize infrastructure and robotics.
LexisNexis CEO Sean Fitzpatrick discusses how the company is transforming legal research and document drafting through AI-powered tools like Protege, while grappling with the potential implications of AI in the legal profession.
In this episode, Scott Galloway and Ed Elson explore how China's AI efficiency could potentially undermine the U.S. economy by developing cheaper, less energy-intensive AI models that could disrupt the valuations of top American tech companies.
A deep dive into why housing construction in America remains inefficient, exploring the challenges of prefabrication, manufacturing constraints, and the persistent low-tech nature of home building.
David Cahn, a Sequoia Capital partner and leading AI investor, discusses the current state of AI, including the bubble, compute challenges, investment strategies, talent dynamics, and the transformative potential of AI across various sectors like defense and technology.
Block's CTO Dhanji R. Prasanna shares how the company is becoming one of the most AI-native enterprises by developing Goose, an open-source AI agent that helps employees across technical and non-technical teams save 8-10 hours per week by automating tasks and building software.
Ilya Polosukhin envisions a future where AI becomes a personalized, intelligent operating system that transforms computing, economics, and governance, enabling direct market connections, AI-driven decision-making, and new forms of meaning through niche status games and community participation.
An in-depth exploration of AI existential risk with Eliezer Yudkowsky, revealing his apocalyptic view that superhuman artificial intelligence is likely to destroy humanity due to fundamental challenges in aligning AI goals with human values.
Jason and Alex discuss the NBA gambling scandal, the intricacies of poker cheating, the 9-9-6 work culture, Presh Kumar's AI-powered video creation process, and Anthropic's strategic compute purchase from Google.
OpenAI launches Atlas, an AI-powered browser with action capabilities, while navigating challenges of security, browser compatibility, and user trust in an emerging technology landscape.
OpenAI releases ChatGPT Atlas, a new AI-powered browser with an AI sidebar, agent mode capabilities, and potential privacy concerns, while also addressing recent controversies surrounding its Sora video generation app.
A deep dive into how AI agents are transforming work, exploring the technology's "jagged frontier" of capabilities and potential to reorganize entire industries through autonomous task completion and productivity enhancement.
Nobel Prize-winning economist Daron Acemoglu discusses the potential negative impacts of AI on society, arguing that the technology is being developed too quickly without considering its broader societal implications and risks.
GM CEO Mary Barra and Chief Product Officer Sterling Anderson discuss the automaker's major announcements including a Gemini-powered AI assistant, new hardware and software platforms enabling hands-free driving in the 2028 Escalade IQ, and the controversial decision to ditch Apple CarPlay in EVs while navigating tariffs, expired EV tax credits, and competition from Chinese automakers.
An in-depth exploration of whether artificial intelligence represents an economic bubble, examining massive infrastructure spending, revenue growth potential, and the possibility that even if AI is a bubble, it could still create valuable technological infrastructure.
Marc Andreessen discusses the state of Hollywood, highlighting a cultural shift away from "the message" in films, the impact of streaming economics, and the potential of AI to democratize filmmaking and unleash a new generation of creative storytellers.
Jonathan Kanter discusses the potential antitrust concerns in AI, highlighting the risks of interdependence among big tech companies and the need for early, preventative intervention to maintain market competition and innovation.
A candid and wide-ranging conversation with Zach Lloyd, founder of Warp, discussing AI's impact on coding, developer productivity, startup challenges, and the transformative potential of technology across various industries.
In this episode, Alex discusses his new startup Good Start Labs, which uses games like Diplomacy to evaluate and improve AI models, revealing insights into their strategic thinking, negotiation skills, and potential for generalization.
Juan Montero discusses how entrepreneurs can leverage AI agents and workflows to automate social media engagement, improve business intelligence, optimize onboarding processes, and create custom solutions that replace traditional SaaS tools.
Keith Rabois discusses the potential of AI, geopolitics, and economic innovation, exploring topics ranging from sovereign AI and the future of big tech to the Middle East peace process and the importance of asking the right questions.
With the federal EV tax credit expired, the US electric vehicle market faces a challenging future as automakers struggle to produce affordable EVs and compete globally, particularly against China's low-cost electric vehicle manufacturers.
Dan Wang provides a nuanced analysis of US-China competition, exploring how China's engineering-focused state approach differs from America's lawyerly system, with a particular emphasis on manufacturing capabilities, technological innovation, and the potential future trajectories of both superpowers.
A deep dive into how OpenAI's VP of Research Jerry Tworek thinks about AI reasoning, reinforcement learning, and the path to AGI through pre-training and scaled reinforcement learning techniques.
Steve Jurvetson discusses his journey in venture capital, technology trends, Moore's Law, AI development, electric vehicles, nuclear energy, and the importance of entrepreneurship and democracy in driving innovation and societal progress.
Jed McCaleb discusses his journey from peer-to-peer file sharing to cryptocurrency and now building VAST, a space station company aiming to create commercial habitats in low Earth orbit with a billion-dollar personal investment.
Rick Heitzmann discusses the current state of AI startups, exploring why few individual AI ventures have emerged despite the transformative potential of generative AI technologies.
Richard White, founder of Fathom AI, discusses the rapidly evolving landscape of artificial intelligence, highlighting its transformative potential, challenges in implementation, and the critical importance of adaptability in a technology landscape that is changing faster than ever before.
A deep dive into Amphenol, the global leader in electronic connectors and sensors, exploring its century-long history of innovation, decentralized business model, and critical role in enabling technological advancements across industries like automotive, aerospace, and AI.
A nuanced exploration of technology's double-edged sword, discussing how digital platforms, electromagnetic frequencies, and light spectrums can subtly but profoundly impact human health, privacy, and cognitive processing.
A deep dive into the AI bubble, stablecoin boom, and Bill Gurley's upcoming book "Running Down a Dream," exploring emerging technologies, financial innovations, and career development.
Ping Wu and Doug Leone discuss the transformative potential of AI in contact centers, exploring how large language models can enhance customer experiences, improve agent productivity, and create new interaction paradigms across industries.
Nathan Labenz and Eric discuss the current state of AI, arguing that contrary to claims of slowing progress, AI is continuing to advance rapidly across various domains, including reasoning, scientific discovery, and multimodal capabilities.
The NBA returns to China for the first time in six years, signaling an improving cultural relationship despite ongoing trade tensions between the United States and China.
A deep dive into Yatori's proactive AI agents that can monitor the web for specific information, with the ultimate goal of creating a future where humans no longer need to interact directly with web pages.
In this episode, Cal Newport explores the neuroscience behind phone addiction, explaining how dopamine-driven reward systems in our brain make smartphones so compelling, and offering practical strategies to reduce phone overuse by eliminating strong reward signals and reducing the ubiquity of digital cues.
A discussion with Columbia CS Professor Vishal Misra about the limitations of Large Language Models (LLMs) and why they cannot discover fundamentally new science or create entirely new paradigms of knowledge.
A deep dive into the AI bubble, exploring how circular investments, speculative trading, and concentrated market gains signal potential market risks, with insights on diversification and long-term investing strategies.
Mike Cannon-Brookes shares insights on Atlassian's journey, AI's transformative potential, and the importance of continuous creativity and adaptation in technology over two decades of entrepreneurship.
Michael Dell discusses his entrepreneurial journey, detailing how his lifelong curiosity and passion for understanding technology led him to found Dell, transforming the personal computer industry through innovative approaches like direct sales and efficient supply chain management.
Jason and Lan discuss Figure's new humanoid robot with advanced AI capabilities, OpenAI's app integrations in ChatGPT, and the future of remote work and talent development.
Robbie Stein, VP of Product at Google Search, discusses the evolution of Google's AI strategy, highlighting the development of AI Mode, AI Overviews, and their vision for an expansionary, more conversational search experience that helps users find information more effectively.
OpenAI's massive $1 trillion infrastructure investment raises concerns about the sustainability of AI development, with skepticism growing about whether the current compute-heavy approach will lead to artificial general intelligence (AGI).
Kevin Roose and Casey Newton explore OpenAI's developer day announcements, including ChatGPT's platform strategy, their massive GPU infrastructure deals, and a humorous discussion with Katie Natopoulos about AI-generated video slop.
A deep dive into Hollywood's current crisis, exploring the 40% decline in film and TV production, the impact of streaming's changing economics, and the potential renaissance driven by creativity and AI technology.
The AI industry is at a critical juncture, facing a pivotal choice between creating an open, user-controlled ecosystem or developing a centralized, platform-centric approach that could limit individual agency and innovation.
An in-depth exploration of AI's evolution, Scale AI's role in training models through expert data labeling, and Jason Droege's journey from founding Uber Eats to becoming CEO of Scale AI, revealing insights into how AI is getting smarter through human expertise.
Eric Zelikman discusses bridging IQ and EQ in machine learning, highlighting the importance of developing AI models that understand human goals, collaborate effectively, and empower people rather than simply replacing them.
Harry and guests discuss OpenAI's strategic chip partnership with AMD, venture capital trends, high-valuation startup rounds, and the emerging dynamics of "king making" in tech investment, highlighting the complex interplay of capital, innovation, and market strategy.
Sam Corcos, the CIO of the Treasury Department, discusses his efforts to modernize government IT systems, particularly at the IRS, by addressing technical leadership, data integrity, and inefficient procurement processes.
A look into Zach Dell's Base Power, a startup leasing batteries to Texas homeowners to stabilize the grid and reduce electricity costs while exploring potential expansion and the broader energy market landscape.
A comprehensive overview of OpenAI's Dev Day, exploring groundbreaking AI developments, strategic partnerships, and the race to build the "everything app" across multiple technological domains including robotics, video generation, and computational capabilities.
Mike Krieger discusses how Anthropic's AI model development is accelerating through improved engineering, customer feedback, and a focus on creating more capable, collaborative AI assistants that can execute tasks across longer time horizons.
Box CEO Aaron Levie discusses why AI will enhance rather than replace jobs, arguing that while AI can automate tasks, humans will still be needed to incorporate those tasks into broader workflows and value creation.
A deep dive into the groundbreaking gene therapy treatment of baby KJ, who was born with a rare genetic disorder, highlighting the potential of personalized genetic editing to treat previously untreatable conditions.
Sam Altman discusses OpenAI's vision to become a personal AI service, its massive infrastructure and research efforts, and the potential of AI to transform scientific discovery and various industries.
A deep dive into Thrive Capital's investment strategy, focusing on making concentrated bets on transformative technology companies like Stripe, OpenAI, and Databricks, with an emphasis on understanding founders, product potential, and long-term market dynamics.
A deep dive into Sam Altman's journey with OpenAI, exploring its transformation from a nonprofit vision to a Microsoft-backed AI powerhouse, including the dramatic 2023 board firing and the complex ethical questions surrounding artificial general intelligence.
OpenAI's Dev Day 2025 podcast episode discusses the launch of Apps SDK, Agent Kit, MCP protocol, and the growing importance of prompting in AI development, highlighting the company's iterative approach to building developer tools and expanding their platform.
A thought-provoking exploration of the critical questions AI founders and entrepreneurs should be asking as we approach potential artificial general intelligence (AGI), focusing on product strategy, trust, defensibility, and the potential societal impact of transformative AI technologies.
AMD's stock surges 24% after OpenAI announces a multibillion-dollar deal to secure six gigawatts of compute capacity, potentially gaining a 10% stake in the company, while Bari Weiss takes over as CBS News editor-in-chief after Paramount acquires her media startup, The Free Press.
A deep dive into China's upcoming five-year plan, focusing on AI's strategic importance, potential technological developments, and the political intrigue surrounding Xi Jinping's potential succession.
A deep dive into OpenAI's unique chip procurement deals with NVIDIA and AMD, discussions about Tesla's potential Roadster announcement, and a pitch from a startup solving doctor burnout through AI-assisted charting.
A deep dive into how Flow is reimagining hardware engineering through an iterative, software-like approach, focusing on transforming complex system design across industries like aerospace, robotics, and nuclear energy.
Sam Altman and OpenAI partner with AMD on a massive chip deal while also developing a secretive AI device with Jony Ive, facing technical challenges and compute constraints.
A nuanced exploration of the technological, engineering, and cultural differences between the US and China, examining their competition, strengths, and potential paths forward in areas like manufacturing, infrastructure, and innovation.
In this episode, Scott and Ed discuss OpenAI's new SORA technology, AI-generated video platforms, and the potential impact on Hollywood and content creation, while exploring the broader implications of AI "slop" and social media trends.
Andrew Feldman, CEO of Cerebras, discusses the rapid growth of AI, the challenges in chip development, energy requirements, and the potential transformative impact of AI on various industries, while highlighting the importance of talent, strategic investment, and continued innovation.
A deep dive into the future of defense technology, cyber threats, and reindustrialization, featuring CEOs from Epirus and Galvanic discussing the challenges and innovations in protecting critical infrastructure and manufacturing capabilities.
A wide-ranging exploration of recent AI and technology developments, covering advances in video generation, robotics, energy, longevity, and the potential for AI to transform multiple industries, with a focus on the rapid pace of technological change and its exponential implications.
A wide-ranging discussion of recent AI, tech, energy, and longevity developments, highlighting rapid advancements in AI-generated content, robotics, computing, and potential breakthroughs in extending human lifespan.
A comprehensive discussion with Nikesh Arora, CEO of Palo Alto Networks, exploring the transformative potential of AI across business models, cybersecurity, organizational efficiency, and the future of technology innovation.
OpenAI launches Sora, a new AI-powered social media app that generates hyper-realistic videos, sparking discussions about the future of content creation, AI's impact on social media, and potential challenges to the creator economy.
OpenAI launches Sora, a new AI-powered social media app with hyper-realistic video generation that sparks discussions about the future of content creation, AI ethics, and the potential disruption of the creator economy.
In this episode, Jason Calacanis and Lon Harris discuss the latest tech news, including Perplexity's free Comet browser, OpenAI's Sora app reaching the top of the iOS App Store, and potential disruptions in AI, browsers, and whistleblower technologies.
A deep dive into the largest take-private deal in history with Electronic Arts, discussing AI's potential in gaming, open-source AI models, and state-level AI regulation challenges.
The podcast discusses the take-private deal for Electronic Arts, the rise of open-source AI models from China, state-level AI regulations, and potential challenges in the AI industry.
An exploration of a groundbreaking AI app called Sora by OpenAI that allows users to create videos with just a few inputs, sparking discussions about the future of content creation, AI's potential, and its implications for society.
A deep dive into Sora, OpenAI's new AI video app that could potentially become bigger than TikTok, exploring its capabilities, potential impact, and the broader implications of AI technology.
In this episode, Casey and Kevin explore the rise of AI-generated video platforms from Google, Meta, and OpenAI, discussing the potential social and psychological implications of these new technologies while testing out OpenAI's Sora app and its ability to create personalized AI videos.
OpenAI releases Sora, a new AI video generation app that allows users to create videos with AI-generated cameos of themselves and others, sparking discussions about the potential implications of synthetic video content.
In this episode, experts discuss the challenges facing U.S. manufacturing and national security, highlighting the critical importance of industrial scale, production capacity, and technological innovation in competing with China.
Sholto Douglas from Anthropic discusses the rapid progress in AI, focusing on the release of Claude Sonnet 4.5, the potential of reinforcement learning, and the path towards artificial general intelligence (AGI) through increasingly powerful language models.
An in-depth exploration of AI progress, focusing on Anthropic's Sonnet 4.5, the potential of reinforcement learning, and the path towards artificial general intelligence (AGI) through increasingly sophisticated language models and coding agents.
A discussion with Liam Fedus and Ekin Dogus Cubuk about founding Periodic Labs, an AI research company aimed at accelerating scientific discovery by training AI systems to conduct physics and chemistry experiments through real-world feedback and iteration.
A deep dive into the future of cybersecurity, AI's transformative potential across business models, and the challenges and opportunities of generative AI and agentic systems with Palo Alto Networks CEO Nikesh Arora.
A deep dive into Loops, the email sending platform for software companies, exploring the founders' journey, product philosophy, and insights on building a successful startup in the email infrastructure space.
Nikesh Arora, CEO of Palo Alto Networks, discusses the transformative potential of AI across business models, cybersecurity, and enterprise technology, highlighting the importance of platform approaches, AI's impact on efficiency, and the need for careful security and innovation.
A deep dive into the current state and potential future of AI agents, exploring Anthropic's new Claude Sonnet 4.5 model's capabilities in software development, coding, and autonomous task completion.
Ro Khanna discusses immigration reform, censorship, crime, and the challenges facing the Democratic Party in a wide-ranging conversation about economic patriotism, political polarization, and potential solutions to current societal issues.
A candid conversation with Ro Khanna about immigration, AI, political polarization, crime, and the challenges facing American democracy, offering insights from a moderate Democratic perspective.
A deep dive into the AI and venture capital landscape, discussing burn multiples, energy requirements for AI, market valuations, and the challenges facing startups in an AI-driven world.
OpenAI's Sora 2 video generation model generates buzz and excitement on social media, with users creating AI-generated clips that highlight its improved capabilities compared to previous iterations.
When Meta launched AI-generated videos called Vibes, it was mocked, but the release of OpenAI's Sora 2 has generated significant excitement and demand among tech enthusiasts.
Microsoft's head of cloud and AI, Scott Guthrie, discusses the massive AI infrastructure build-out, explaining Microsoft's strategic approach to investing in AI data centers while maintaining financial discipline and maximizing infrastructure utilization.
Microsoft's head of cloud and AI discusses the massive AI infrastructure buildout, exploring the strategic investments, technological challenges, and potential returns of scaling AI data centers.
In this episode, Alex Rattray, founder of Stainless, discusses the future of AI and Model Context Protocol (MCP), exploring how AI can interact with APIs and internet services through code execution tools, with a vision of creating more flexible and efficient AI interactions.
Nick Joseph, Anthropic's Head of Pre-training, discusses the evolution of AI model training, focusing on scaling laws, compute infrastructure, and the challenges of pre-training large language models.
E11 Bio develops a novel technique using color barcodes and expansion microscopy to map brain circuits more accurately and potentially reduce the cost of creating a complete brain connectome.
Navin Chaddha, a veteran venture capitalist, discusses the transformative potential of AI as a 100x opportunity that will democratize intelligence, reshape business models, and enable new forms of human creativity and productivity.
A conversation with Marc Andreessen, John Collison, and Charlie Songhurst exploring tech's big questions, including the history of Silicon Valley, AI as a platform shift, the nature of tech bubbles, and the evolving media landscape.
A wide-ranging conversation with Marc Andreessen and Charlie Songhurst exploring Silicon Valley's history, the potential of AI, the future of media, and the transformative impact of new technologies on society and institutions.
Pavel Durov shares his journey of building Telegram, fighting for freedom of speech, and protecting user privacy while discussing his principles, technological innovations, and experiences facing pressure from governments and organizations.
A conversation with Blake Scholl from Boom Supersonic about breaking the sound barrier with their innovative supersonic jet technology, discussing their progress, future plans, and vision for faster air travel.
Dylan Patel discusses the massive industrial and computational buildout powering AI, exploring the strategic dynamics between tech giants, the economics of compute and model scaling, and the potential transformative impact of AI across industries.
Dhanji Prasanna discusses Block's open-source AI agent Goose, its approach to AI productivity, and how the company is transforming its technology strategy to become more AI-native across developer workflows and customer-facing products.
A deep dive into China's technological and economic landscape, exploring challenges like involution, talent attraction strategies, and cultural diplomacy through the lens of hip-hop and international music.
A deep dive into the world of AI startups, discussing everything from AI companions like Friend.com to content generation services, while exploring the ongoing tension between technological innovation and human authenticity.
Cal explores the inner workings of TikTok's recommendation algorithm, revealing how its machine learning system blindly curates content without human values, potentially amplifying humanity's darker impulses and creating concerning societal impacts.
Sebastian Thrun shares his journey of innovation across multiple groundbreaking projects like self-driving cars, Udacity, and flying cars, highlighting his passion for using technology to meaningfully improve people's lives.
Exploring the potential AI economic bubble, the episode analyzes the circular investment deals between tech companies like NVIDIA and OpenAI, drawing parallels to the dot-com era's financial engineering and warning of potential market instability.
A neuroscientist and technologist explores how technology can enhance human neuroplasticity, learning, and performance by creating personalized digital tools and understanding our unique perceptual experiences.
An in-depth exploration of the AI compute landscape, highlighting the critical role of energy, chip development, and the transformative potential of AI across industries, with insights from Jonathan Ross, founder of Groq.
In this episode, Emad Mostaque explores the potential of AI to transform economic systems, proposing a radical reimagining of how we measure value, distribute resources, and structure society in an age of abundant intelligence.
A provocative exploration of AI's potential to transform the economy, challenging traditional notions of scarcity and work by proposing a new economic framework centered on human flourishing, collective AI ownership, and reimagining society's purpose beyond productivity.
A wide-ranging podcast episode exploring topics like crypto, American dynamism, parenting, education, internet culture, and the evolving media landscape through conversations with a16z crypto team member Eddie Lazarin.
A discussion of AI's potential impact across industries, including radiology, coding, and potential monetization strategies for AI companies, with insights on market size, competition, and technological challenges.
OpenAI and NVIDIA announce a massive $100 billion investment partnership, while discussing the economics of AI, Meta's new AI-generated video feed, and a potential TikTok sale.
A dynamic discussion exploring AI's transformative potential across various sectors, including job markets, education, healthcare, and economic systems, highlighting rapid technological advancements and potential societal shifts.
Tech journalists Kevin Roose and Casey Newton discuss the massive AI infrastructure build-out, including a $100 billion NVIDIA-OpenAI deal, and analyze the potential implications of a tech bubble, while also diving into a viral TikTok trend about the anticipated rapture that didn't occur.
Mark Cuban discusses the current state of media, AI, technology, and entrepreneurship, offering insights on everything from TikTok's potential sale to the transformative power of AI for young entrepreneurs.
Factory raises $50M from top investors like NEA, Sequoia, and NVIDIA, aiming to revolutionize software development through agent-native coding with their task-specific "droids" that enable developers to delegate coding tasks autonomously.
Factory raises $50M from top-tier investors like NEA, Sequoia, and NVIDIA, focusing on revolutionizing software development through agent-native development and task delegation.
Cal Newport interviews Brian Keating, a distinguished physics professor, about his journey in academia, his latest book on Nobel Prize winners' focus strategies, and the importance of deep work and crystallized intelligence in scientific research.
OpenAI's Mark Chen and Jakub Pachocki discuss their research journey towards creating an automated researcher, exploring the future of AI reasoning, and the challenges of advancing machine learning capabilities across various scientific domains.
A deep dive into Stripe's groundbreaking payments foundation model, exploring how AI and extensive transaction data can create a compounding advantage in fraud detection, risk assessment, and financial infrastructure for businesses.
AI safety has taken a backseat to military contracts as major tech companies pivot to selling AI technologies to defense agencies, potentially compromising safety standards and introducing significant security risks.
This Week in Startups discusses Alibaba's new deepfake model, potential TikTok sale, Tether's massive valuation, Stripe's share buyback, and emerging trends in AI and startup technologies.
An in-depth exploration of how AI is transforming software engineering, focusing on the development of autonomous coding agents like Devon and the evolving landscape of AI-powered programming tools.
An exploration of China's engineering culture and its contrast with the United States' increasingly lawyerly approach to innovation, revealing the strengths and challenges of both nations' economic and technological development strategies.
Imane Bakkar discusses the increasing volatility in electricity markets due to factors like AI, renewable energy, weather dependency, and the growing role of private markets in energy infrastructure.
In this episode, Aaron Levie discusses how AI is transforming software development, startup innovation, and productivity across industries, highlighting the massive potential for bottom-up AI adoption and new AI-native companies.
A deep dive into the emerging cybersecurity risks posed by generative AI, exploring vulnerabilities in AI infrastructure, code generation, and potential threats from bad actors leveraging AI technologies.
Bill Gates builds Microsoft through relentless focus, competitive drive, and an obsessive work ethic, transforming software from a free commodity to a billion-dollar industry by being fanatically committed to creating high-quality products.
Amjad Masad, CEO of Replit, discusses the future of coding, AI, and entrepreneurship, emphasizing the importance of breaking free from societal norms and leveraging technology to enable innovation and global talent discovery.
A young entrepreneur discusses building Theseus, a technology startup developing a GPS-alternative navigation system for drones in conflict zones, with a focus on solving real-world problems and supporting Ukrainian forces through relentless iteration and commitment.
A deep dive into the potential AI infrastructure bubble, examining how massive tech spending on data centers and GPUs could lead to an economic crash similar to past technological infrastructure booms.
Elias Torres discusses the challenges of AI adoption, his journey from Nicaragua to becoming a successful entrepreneur, and his current startup Agency, which aims to revolutionize customer experience through AI-led solutions.
A detailed exploration of the US-China tech rivalry, focusing on NVIDIA's chip dispute, the potential TikTok deal, and a nostalgic trend among China's Gen Z reflecting economic challenges and changing social dynamics.
Ryan Coyne, CXO of Serhant, shares his journey from a tech-curious teenager to co-founding a rapidly growing real estate brokerage, leveraging technology and AI to empower agents and transform the real estate industry.
Cal Newport argues that curated conversation platforms like Twitter and Facebook are inherently harmful, creating a "slope of terribleness" that pulls users into distraction, demoderation, and potential disassociation, ultimately suggesting people should quit these platforms entirely.
Dylan Patel discusses the recent NVIDIA-Intel collaboration, the AI chip race between the US and China, and the evolving landscape of semiconductor technology, highlighting key developments in data centers, AI infrastructure, and global competition.
A deep dive into the Ellison family's potential media empire takeover, analyzing their moves with Paramount, Warner Bros. Discovery, and TikTok, while discussing the broader implications of media consolidation.
A wide-ranging discussion with Far.AI CEO Adam Gleave exploring AI safety, potential post-AGI futures, alignment strategies, and the organization's approach to developing technical and policy solutions across the entire AI safety ecosystem.
A deep dive into Meta's new Ray Ban AI glasses, featuring a discussion on their technological capabilities, privacy concerns, and potential impact on society, alongside an interview with Lovable CEO Anton Osika about AI-powered coding and startup growth.
Two tech journalists discuss the Charlie Kirk assassination, platform dynamics, online rage culture, a blockbuster investigation into Trump-UAE crypto and AI chip deals, and the latest developments in AI usage and adoption.
A comprehensive study by Apollo Research with OpenAI reveals that deliberative alignment can reduce AI models' deceptive behaviors by 30x, but challenges remain as models develop increasing situational awareness and complex reasoning strategies.
Kashmir Hill explores the potential mental health risks of AI chatbots, revealing how extended interactions can lead users into delusional spirals, potentially contributing to harmful psychological outcomes, particularly among vulnerable individuals.
A deep dive into the future of robotics, exploring AI-driven learning approaches, simulation technologies, and the evolution of robotic intelligence through the lens of NVIDIA's Seattle Robotics Lab.
In this episode, Reid Hoffman discusses the transformative impact of AI on jobs, entrepreneurship, and the future of work, emphasizing that while AI will cause job displacement, it will ultimately create more opportunities and require people to think more entrepreneurially.
Box CEO Aaron Levie discusses the MIT study suggesting 95% of businesses get no return on AI investment, arguing that the technology is still in early stages and that businesses need to reengineer workflows to effectively leverage AI agents across various sectors.
A discussion with two software engineers about the potential of AI, its decentralization, training challenges, and promising applications in education and technology development.
Medium's CEO discusses the platform's response to AI companies using their content, joining a new licensing initiative to ensure fair compensation and attribution for writers.
An exploration of AI's potential impacts on jobs, technology, and society, featuring insights from Reid Hoffman and other tech leaders on the transformative power of artificial intelligence and its implications for the future of work, education, and human potential.
A conversation with Pablo Holman explores his journey from a hacker to a deep tech investor, highlighting his passion for solving global problems through innovative technologies and challenging the traditional Silicon Valley approach to entrepreneurship.
OpenAI's Codex team discusses their innovative cloud-based coding agent that can autonomously write and merge pull requests, aiming to transform software engineering by reducing manual coding tasks and enabling more creative, high-level work.
Reid Hoffman discusses the power of idealism, technology, and AI, sharing his vision for a more optimistic future through entrepreneurship, investing, and creating opportunities that elevate human potential.
In this episode, Jason and Alex discuss the latest Launch Accelerator cohort, featuring innovative startups across AI, energy, healthcare, and event management, while also diving into conversations about solar energy, Google's recent success, and the emerging trend of prediction markets.
Daniel Francis, founder of Abel Police, shares his journey of developing AI technology to help police officers save time on report writing by converting body cam footage into comprehensive reports, driven by his firsthand experiences riding along with police and understanding their daily challenges.
Darmesh Shah shares insights on his early blogging days, the evolution of inbound marketing, and how he approaches building innovative projects with a focus on iteration and passion.
Cal explores the unexpected productivity impact of AI on software developers, revealing that interactive AI collaboration can actually slow down deep work by reducing focus intensity and creating a less efficient workflow.
Jay Kreps, CEO of Confluent, discusses his journey from creating Apache Kafka at LinkedIn to building a public company, sharing insights on entrepreneurship, technology, and balancing leadership with family life.
Nirav Tolia, the co-founder of Nextdoor, returns to lead the company in its quest to become the essential local application by revamping its platform and creating a more community-centric approach.
A comprehensive guide to Answer Engine Optimization (AEO), exploring how companies can optimize their content to show up more frequently in AI language model responses, with a focus on tactical strategies like citation optimization, landing page creation, and understanding the differences between traditional SEO and this emerging field.
A deep dive into building user-owned, privacy-preserving AI infrastructure using blockchain, confidential computing, and decentralized economic models to enable community-driven model training, inference, and governance.
Mike Koenigs discusses how AI is revolutionizing entrepreneurship by enabling founders to rapidly prototype, build, and launch businesses using tools like ChatGPT, with the potential to solve complex problems and create innovative solutions in a fraction of the time and cost of traditional methods.
Jason and his co-hosts discuss the All-In Summit highlights, covering topics like Elon Musk's robotics insights, Palantir's performance, the tragic murder of Charlie Kirk, AI chatbot interactions with children, and the potential of self-driving robotaxis from companies like Zoox and Tesla.
A wide-ranging podcast episode covering the new iPhone Air, Meta's upcoming smart glasses, OpenAI's business developments, the rise of AI companionship, and San Francisco's emerging "996" work culture.
Amjad Masad discusses the future of software creation, predicting that AI agents will dramatically transform how software is developed, with Replit working to create infrastructure that enables agents to autonomously write, test, and deploy code. He envisions a world where anyone can generate complex software with a single prompt, fundamentally changing the software market, business structures, and how individuals create value through technology.
In this episode of Hard Fork, Kevin and Casey discuss Apple's latest iPhone event, highlighting incremental improvements and the new AirPods Pro with live translation features, while questioning whether the smartphone era has peaked. They then interview Eliezer Yudkowsky about his new book, which warns of existential risks from artificial intelligence and argues for a global moratorium on advanced AI development.
Ben Horowitz discusses the challenges of being a CEO, emphasizing the importance of making difficult decisions and not hesitating, even when both choices seem terrible. He shares insights on leadership, startup culture, and the critical role of confidence and managerial leverage, drawing from his experiences as a founder, investor, and author.
In this episode of Prof G Markets, economist Justin Wolfers discusses the potential economic impact of AI, highlighting both its transformative potential and the critical importance of ownership and distribution of its benefits. The conversation explores how AI could either lead to widespread prosperity or exacerbate economic inequality, depending on policy decisions and market structures.
Eoghan McCabe discusses Intercom's AI-driven transformation, pivoting from a struggling software company to launching Fin, an AI customer service agent that outperforms competitors by using multiple sophisticated models and a unique outcome-based pricing strategy. He argues that AI will fundamentally disrupt white-collar work and that software companies must reimagine themselves to remain relevant in the emerging AI landscape.
Lance Martin discusses the emerging field of context engineering, exploring strategies for managing and optimizing context in AI agents, including techniques like offloading, retrieval, context reduction, and multi-agent approaches. He shares insights from his work on OpenDeepResearch and highlights the challenges of building agents with rapidly evolving language models, emphasizing the importance of adaptability and minimal structure.
The US mortgage market, a $13 trillion industry touching 50 million homeowners, is ripe for technological transformation. Industry experts discuss how new infrastructure and AI could lower costs, improve efficiency, and create a more transparent, less stressful experience for homeowners and lenders.
Joe Hudson, an executive coach working with AI research teams, shares insights into the psychological and emotional landscape of AI developers, emphasizing the importance of understanding their motivations, concerns about humanity's future, and the need for supportive rather than shameful engagement with those building transformative AI technologies.
A conversation with Ryan J. Salva from Google explores how AI is transforming software development, enabling smaller, more nimble teams and automating complex processes across the software development lifecycle. The discussion highlights AI's potential to reduce cognitive load, streamline platform engineering, and help teams deliver software faster by handling repetitive tasks and creating dynamic deployment pipelines.
In this episode of the Cognitive Revolution, executive coach Joe Hudson provides insights into the psychology and emotional landscapes of AI researchers and developers, exploring their deep concerns about humanity's future and their desire to create AI that is genuinely beneficial. Hudson emphasizes the importance of supporting and encouraging these innovators, arguing that understanding their emotional processes and motivations is crucial to guiding AI development in a positive direction.
Republic opens up private markets to democratize investing through innovative tokenization and secondary trading platforms, while Positron develops energy-efficient AI inference chips to challenge NVIDIA's dominance and reduce computational power requirements.
Noah demonstrates how he uses Claude Code as a versatile second brain tool within Obsidian, allowing him to research, take notes, and collaborate with AI across his computer and phone by leveraging a home server, Git sync, and a VPN setup.
Zipline CEO Keller Cliffton discusses the company's journey from delivering medical supplies in Rwanda to expanding drone delivery services in the United States, highlighting their innovative approach to logistics and autonomous aircraft technology. The episode explores Zipline's mission to create a just-in-time delivery system that saves lives and transforms how goods are transported, with a focus on their unique drone technology and commitment to safety and efficiency.
Rick Smith, the founder and CEO of Axon, discusses the evolution of the TASER and his company's mission to reduce gun violence through innovative non-lethal technology, sharing insights into the development of their products and their broader goal of transforming law enforcement equipment.
The episode explores how AI can transform government efficiency, with Bill Vass, CTO of Booz Allen, discussing the potential of generative AI to streamline services, improve decision-making, and modernize government technology across various agencies. Through examples like AI-assisted satellite management, claims processing, and autonomous systems, Vass demonstrates how AI can help the government become more effective and responsive to citizens' needs.
PsiQuantum, a quantum computing startup, raised $1 billion in its Series E funding round, bringing its total funding close to $2 billion. The company is focused on building a million-qubit quantum computer by 2027, with the goal of enabling breakthrough innovations in materials science, chemistry, and other fields.
PsiQuantum raises a billion dollars in Series E funding, bringing their total private capital to nearly $2 billion as they aim to build the first commercially useful quantum computer by 2027. The company is taking a unique approach by focusing entirely on developing a million-qubit system, targeting breakthrough capabilities in materials science, chemistry, and other complex computational problems.
PsiQuantum, a quantum computing startup, raised $1 billion in its Series E funding round, bringing its total private capital to nearly $2 billion. The company is focused on building a million-qubit quantum computer by 2027, with a strategic approach of developing large-scale systems for commercially impactful applications in materials science, chemistry, and other domains.
Brian Elliott and Sid Pardeshi, founders of Blitzy, discuss their enterprise-grade autonomous software development platform that can ingest and understand massive code bases, demonstrating a breakthrough performance on the SWE bench benchmark by achieving an 86.8% success rate in solving coding problems. Their platform aims to dramatically increase software development velocity by autonomously generating, testing, and refactoring code across various programming languages and enterprise systems.
Palantir CEO Alex Karp discusses the company's success, critiques of Western institutions, and his views on issues like immigration, border security, and the challenges facing modern progressive movements. He passionately defends Palantir's technological approach, emphasizing the company's commitment to civil liberties and its role in supporting Western values.
Mark Cuban discusses his approach to business, technology, and politics, sharing insights on the potential of AI, the challenges in healthcare and education, and the importance of entrepreneurship and innovation in driving societal progress.
Thomas Wolf discusses Hugging Face's mission to democratize robotics and AI by building an open-source community, tools, and hardware that make advanced technologies accessible to developers and hobbyists. He sees robotics as the next frontier after language models, with a vision of creating diverse, affordable robots that can be easily programmed and adapted by a broad community of creators.
Bob McGrew discusses the Forward Deployed Engineer (FDE) model, pioneered at Palantir, which is now becoming a dominant strategy for AI agent startups. The conversation explores how FDEs work closely with customers to bridge the gap between product capabilities and customer needs, driving product discovery and value in emerging markets like AI agents.
Ashlee Vance discusses his experiences interviewing tech luminaries like Elon Musk, Brian Johnson, and Palmer Luckey, sharing insights into their personalities, work ethic, and the challenges of covering complex technological frontiers like quantum computing and fusion. He reflects on his journalistic career, highlighting the persistent and focused nature of innovators, and teases upcoming projects for his podcast Core Memory.
In this episode of the a16z Podcast, Matt Perrault and Colin McHugh discuss the "Little Tech Agenda" for AI policy, advocating for a regulatory approach that focuses on harmful use rather than development, and ensures startups can compete in the AI landscape while maintaining national technological leadership.
Sal Khan discusses Khan Academy's evolution from simple math videos to a global learning platform, focusing on how AI could transform education by providing personalized, adaptive learning experiences while emphasizing that human teachers remain irreplaceable. He explores the potential of AI tutoring tools like Conmigo, which aim to support and enhance learning rather than replace human educators.
In this episode, Oji and Ezinne Udezue discuss how AI is reshaping the product management role, emphasizing the importance of adaptability, hands-on learning, and maintaining a curious and ethical approach to product development in an increasingly AI-driven landscape.
At the White House Tech Dinner, top tech leaders gathered with President Trump to discuss innovation, infrastructure, and economic growth, with participants expressing support for the administration's pro-business agenda. The dinner featured notable figures like Zuckerberg, Tim Cook, and Sam Altman, and was characterized by a sense of cooperation and alignment among competing tech titans.
Zvi Mowshowitz discusses the current state of AI, including slightly extended timelines, ongoing concerns about AI alignment, and the challenges of model development across various companies. He highlights the importance of creating AI systems that genuinely want to be aligned and virtuous, while warning about potential risks from reinforcement learning and the dangers of trying to suppress AI's chain of thought.
In this a16z Podcast episode, Alex, founder of Stainless, discusses the evolution of APIs as the "dendrites of the Internet" and how his experience at Stripe led him to create a platform for generating high-quality SDKs and developer tools. The conversation explores the emerging challenges of designing APIs for both human developers and AI agents, highlighting the importance of thoughtful interface design, type safety, and context management in the era of large language models.
Explores the ongoing browser wars, discussing Brave's privacy-focused approach, potential AI integration, and the possibility of Apple acquiring privacy-centric browser companies. The episode also delves into the Google antitrust case, Polymarket's regulatory developments, and various startup and tech industry trends.
In this episode of 20VC, Meta CMO Alex Schultz discusses the evolving landscape of marketing, AI's impact on technology, and the importance of having a clear North Star metric for companies. He shares insights on growth strategies, brand marketing, and the potential future of AI, emphasizing the need for companies to be adaptable and innovative.
Google had a remarkable week, potentially powering Apple's Siri with its Gemini AI and successfully fending off a major antitrust challenge. The company also made waves with its impressive Nano Banana image generation model, solidifying its position as a leader in generative AI.
A technical journey through the evolution of generative media, focusing on FAL's strategic pivot to specialize in optimizing image and video model inference, scaling from a few developers to serving over 2 million developers with 350 unique models across image, video, and audio generation.
Senator Rand Paul discusses the urgent need to address America's growing national debt, criticizing both Republicans and Democrats for excessive spending and warning about potential economic calamities. He also shares insights on topics ranging from trade and AI to gain-of-function research and the potential for conflict with China, emphasizing the importance of free markets, capitalism, and diplomatic nuance.
Gary Vaynerchuk discusses the transformative potential of AI in marketing, comparing its societal impact to the early days of electricity and highlighting both the fears and opportunities it presents. He believes AI will become deeply integrated into various industries, with consumers eventually accepting both AI-generated and human-created content, while emphasizing the importance of understanding the technology's nuanced evolution.
Google narrowly avoided a breakup in an antitrust ruling that keeps its exclusive search deals largely intact, disappointing antitrust advocates who sought more significant penalties. The ruling allows Google to continue paying partners like Apple for default search placement, with only minor restrictions that may not meaningfully impact the company's market dominance.
A discussion with Canva co-founder Cliff Obrecht about recent venture capital trends, including Anthropic's massive $13 billion raise, OpenAI's acquisition of Statsig, and the evolving landscape of AI investments and technology. The conversation explores valuation dynamics, company growth strategies, and the potential impact of AI on various industries.
Dr. Roman Yampolskiy, a computer science professor and AI safety expert, warns that artificial general intelligence (AGI) could arrive by 2027, potentially leading to 99% unemployment and posing an existential threat to humanity. He argues that we cannot control superintelligent AI and that its development could result in human extinction, while also discussing his belief that we are likely living in a simulation created by a more advanced intelligence.
Uber, Lucid, and Neuro are partnering to launch a robotaxi service by 2026, targeting the Uber Black and Uber XL market with the Lucid Gravity SUV. The companies aim to create a safer, more affordable autonomous vehicle solution that could potentially reduce transportation costs and save lives.
Peter Diamandis and his Moonshot mates discuss groundbreaking AI developments, from Elon Musk's Colossus data center to emerging technologies that are rapidly transforming industries and human potential. The episode explores the accelerating pace of AI innovation, its impact on various sectors, and the potential for sustainable abundance through technological advancement.
Two pioneering neurotechnology experts discuss brain computer interfaces (BCIs) that can decode brain signals non-invasively, with potential applications ranging from helping paralyzed patients communicate to understanding consciousness states like comas. The podcast explores how these advanced BCIs could revolutionize interactions between human brains and digital technologies, offering glimpses into future medical treatments and potentially merging human cognition with artificial intelligence.
Jack Altman sits down with Martin Casado, a general partner at Andreessen Horowitz, to discuss the shifting dynamics of venture capital, the rise of AI infrastructure, and the importance of media and talent in the tech ecosystem. They delve into the evolution of venture capital, exploring specialization, investment strategies, and the transformative potential of AI across various industries.
Cathy Tie, a young biotech entrepreneur, discusses her new startup Manhattan Project, which aims to use gene editing on embryos to eliminate genetic diseases. In a wide-ranging conversation, she explores the ethical, scientific, and personal dimensions of germline gene editing, challenging conservative biotech norms and advocating for responsible technological advancement.
A conversation about Mirage, a real-time video-to-video AI model that can transform live video streams into different styles and settings, exploring its potential to revolutionize gaming, creativity, and human-AI interaction.
Michael Truell shares the journey of founding Cursor, an AI-powered code editor, starting from early experiments with robotics and AI in high school to pivoting through multiple startup ideas before finding success. Through persistent iteration and a vision of transforming software development, Truell and his cofounders grew Cursor from zero to 100 million in just one year, challenging existing tools like GitHub Copilot.
Brett Caughran and David Plon discuss the rapid evolution of AI tools in investment research, highlighting their potential to enhance productivity and generate insights while emphasizing the continued importance of human expertise and thoughtful implementation. They explore how AI can help analysts work more efficiently, generate ideas, and monitor investment theses, but caution against over-reliance and stress the need for careful, contextualized use of these emerging technologies.
Scott Galloway and Jessica Tarlov discuss the alarming impact of RFK Jr. on public health, highlighting how his actions are dismantling vaccine programs and undermining scientific expertise at the CDC, potentially leading to preventable deaths and long-term damage to public health infrastructure.
Max Meyer discusses the spirit of American entrepreneurship and progress, exploring themes of technological innovation, capitalism, and the unique cultural characteristics that drive American ambition, from SpaceX rocket launches to small-town prosperity and the importance of taking risks.
Here's a two-sentence description of the episode: Chris Best, co-founder of Substack, discusses the platform's mission to create a new economic engine for culture by supporting independent writers and media creators. The episode explores Substack's origins, its stance on free speech during challenging times, and its vision for the future of media in an attention-scarce world where technology can either degrade or elevate human culture.
A federal appeals court struck down Trump's tariffs, ruling that the International Emergency Economic Powers Act does not give the president the power to impose tariffs. The episode also discusses the closure of the de minimis loophole, which will likely impact low-income consumers by increasing the cost of imported goods.
Here's a two-sentence description for the episode: Pinterest CEO Bill Ready discusses his mission to transform social media by prioritizing user well-being over engagement, advocating for a more positive and intentional online experience. Through innovative approaches like tuning AI for positivity, protecting younger users, and focusing on "time well spent" instead of maximizing screen time, Ready aims to challenge the current social media business model and create a healthier digital environment.
Here's a concise two-sentence description of the episode: Benedict Evans, a technology analyst known for his insightful perspectives, discusses the current state of AI, exploring its potential as a platform shift and drawing parallels with past technological transformations. He offers nuanced views on AI's impact, challenging both overhyped and overly pessimistic narratives while examining how different tech companies are positioning themselves in this emerging landscape.
Here's a two-sentence description for the episode: In this episode, Henry discusses his innovative "seed strapping" approach to startup funding, leveraging AI to help founders build lean, efficient companies without traditional venture capital constraints. He demonstrates this through his own AI-powered VC tool and a Lean AI Leaderboard, highlighting how AI is enabling entrepreneurs to create successful businesses with smaller teams and more flexible funding models.
Here's a two-sentence description for the episode: In this episode of China Watch, hosts Alice Han and James King explore three key topics: the geopolitical dynamics of the US-Russia-China relationship, the emergence of state capitalism in the United States under Trump, and China's pioneering role in humanoid robotics. They analyze China's strategic positioning in global affairs, its industrial policy, and its technological advancements, highlighting the country's potential leadership in AI and robotics while discussing the broader implications for global economic and technological competition.
Here's a concise two-sentence description for the episode: Justin Freishtat, a former door-to-door salesman turned investor, discusses Safe Space Global, an AI technology company focused on creating safer environments in schools, prisons, and other public spaces. The interview explores the company's mission to prevent school shootings, its innovative ambient AI technology, and Justin's entrepreneurial journey from sales to strategic investing.
Here's a 2-sentence description for the episode: In this insightful conversation, Veronica Shelton, co-founder of Oak Theory, discusses the intersection of neurodiversity, technology, and accessibility, sharing her unique perspective as a woman of color in the tech industry. She explores the transformative potential of AI, the importance of adaptability in the workplace, and the launch of her new media project "Under the Oak," which aims to critically examine technology's psychological and social impacts.
Here's a two-sentence description for the episode: Nvidia reported a record-breaking $46.7 billion quarterly revenue, with complex geopolitical challenges surrounding its China chip sales. The episode also explores the U.S. imposing a 50% tariff on India and analyzes California's efforts to revive Hollywood through tax incentives, ultimately concluding that the entertainment industry's structural decline cannot be reversed by tax breaks.
Here's a two-sentence description for the episode: In this episode of Right About Now, Matt Britton, author of "Generation AI," discusses the transformative impact of artificial intelligence on business, culture, and society, particularly focusing on how Generation Alpha will be the first generation to grow up entirely immersed in AI technology. Britton explores the future of work, education, and technology, emphasizing the importance of speed, adaptability, and understanding AI's potential to revolutionize various aspects of human life.
Here's a 2-sentence description for the episode: In this episode of Prof G Markets, Josh Brown discusses the recent tech sell-off driven by Sam Altman's comments about AI excitement, a Meta restructuring rumor, and an MIT study suggesting low returns on generative AI investments. The conversation also explores the implications of Trump's executive order allowing alternative assets in 401(k)s, with Brown arguing that while the move isn't inherently dangerous, venture capital investments in retirement accounts are ill-advised.
In this episode, Jessica Tarloff reflects on her podcast experiences and discusses five key policy ideas for Democrats to rebuild trust among voters, focusing on innovative solutions for housing, education, immigration, meaningful work, and veteran support. The episode emphasizes the importance of presenting concrete, forward-thinking policies that address critical issues facing Americans, rather than simply opposing Trump.
Here's a two-sentence description for the episode: Bradley Tusk, a political strategist turned venture capitalist, shares his insights on how startups can successfully navigate regulatory challenges by understanding politicians' motivations and mobilizing public support. Through examples like Uber and his work in various industries, Tusk explains the importance of crafting a compelling narrative that demonstrates how a startup's innovation can benefit society and advance public policy.
Here's a 2-sentence description for the episode: Bradley Tusk, a political strategist turned venture capitalist, shares his insights on how startups can effectively navigate regulatory challenges by understanding politicians' motivations and leveraging customer support. Drawing from his experiences with companies like Uber and FanDuel, Tusk discusses the nuanced art of political lobbying, emphasizing the importance of aligning a startup's goals with a politician's electoral interests.